1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea

1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea 화학적 특성, 용도, 생산

• 일반 설명

  A cell-permeable 3-aminoindazolylurea compound that acts as a potent and ATP-competitive inhibitor of VEGFR2/KDR (IC₅₀ = 3 nM) as well as Flt3 and cKit (IC₅₀ = 4 to 20 nM). Shown to block VEGF-induced VEGFR2 phosphorylation in 3T3-murine fibroblasts in vitro (IC₅₀ = 13 nM) and exhibit oral availability (AUC = 6.5 μM?h with an oral dose of 10 mg/kg in CD-1 mice) and in vivo efficacy in a murine estradiol-induced uterine edema model (ED₅₀ = 4 mg/kg p.o. in balb/c mice).

1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea 공급 업체

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