Chapso

한글명:Chapso

카스 번호82473-24-3

상품명:Chapso

CBNumberCB7323821

분자식C32H58N2O8S

포뮬러 무게630.88

MOL 파일82473-24-3.mol

화학적 성질

녹는점	184-186 °C(lit.)
밀도	1.0453 (rough estimate)
굴절률	1.6900 (estimate)
저장 조건	-20°C
용해도	H₂O: 10 mg/mL at 20 °C, 투명, 무색
물리적 상태	흰색 고체
색상	백색 결정체
냄새	냄새 없는
수용성	20°C에서 10g/l
Merck	13,2052
BRN	5842642
CAS 데이터베이스	82473-24-3(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기	Xi
위험 카페고리 넘버	36/37/38
안전지침서	26-36
WGK 독일	3
F 고인화성물질	3-10
HS 번호	2924297099

그림문자(GHS)

Chapso 화학적 특성, 용도, 생산

화학적 성질
Chapso is a white crystalline powder. It is a zwitterionic detergent similar to Chaps, however, Chapso is more soluble and particularly better for the solubilization of integral membrane proteins.
용도
Chapso is a nondenaturing biological detergent with characteristics similar to CHAPS, although it is more soluble due to a more polar head group. Useful for the solubilization of integral membrane proteins.
주요 응용
3-(cholamidopropyl)(dimethylammonio)-2-hydroxy-1-propanesulfonate (CHAPSO) may be used in bicelle preparation for β2-adrenergic receptor reconstitution.
CHAPSO has been used:
in a study to assess the processes of liposome solubilization and reconstitution of two transport proteins
in a study to investigate a novel bicelle system for orienting macromolecules over a wide temperature range
as a mixture with dilauroyl phosphatidylcholine (DLPC) in solid-state nuclear magnetic resonance (NMR) technique to study membrane-associated proteins
A nondenaturing zwitterionic detergent with characteristics similar to CHAPS, although it is more soluble due to a more polar head group. Useful for the solubilization of integral membrane proteins.
일반 설명
CHAPSO is a non-denaturing zwitterionic bile salt derivative, derived from Chaps by the addition of a functional hydroxyl group.
Purification Methods
Dissolve this zwitterionic detergent (~ 60g) in 40% aqueous MeOH and stir it with the mixed-bed ion-exchange resin RG-501 x 8 (100g, Bio-Rad) until the pH of the supernatant is ~ 7. Filter off the resin and evaporate the filtrate to dryness under reduced pressure. Check for homogeneity by TLC on silica gel G in 95% MeOH/5% NH4OH and visualize the spot with iodine vapour (see CHAPS above). [Hjelmeland et al. Anal Biochem 130 72 1983, Matuo et al. Methods Enzymol 198 155 1991.]

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