1,2,3,4-Tetrahydroquinoline

한글명:1,2,3,4-Tetrahydroquinoline

카스 번호635-46-1

상품명:1,2,3,4-Tetrahydroquinoline

CBNumberCB7286982

분자식C9H11N

포뮬러 무게133.19

MOL 파일635-46-1.mol

화학적 성질

녹는점	9-14 °C (lit.)
끓는 점	113-117 °C/10 mmHg (lit.) 249 °C (lit.)
밀도	1.061 g/mL at 25 °C (lit.)
굴절률	n20/D 1.593(lit.)
인화점	213 °F
저장 조건	Keep in dark place,Sealed in dry,Room Temperature
물리적 상태	액체
산도 계수 (pKa)	5.09±0.20(Predicted)
색상	맑은 연한 노란색에서 노란색까지
냄새	디프로필렌 글리콜 중 1.00%. 꿀 사향고양이 동물 페놀릭
수소이온지수(pH)	10-11 (111g/l, H2O, 20℃)(as an emulsion)
?? ??	동물
수용성	<1g/L(20℃)
어는점	11.0 to 20.0 ℃
BRN	116149
LogP	2.290
CAS 데이터베이스	635-46-1(CAS DataBase Reference)
NIST	Quinoline, 1,2,3,4-tetrahydro-(635-46-1)
EPA	1,2,3,4-Tetrahydroquinoline (635-46-1)

위험 및 안전 성명

위험품 표기

Xi,T

위험 카페고리 넘버

36/37/38-45

안전지침서

26-36/37-36-45-53

WGK 독일

TSCA

Yes

HS 번호

29334990

NFPA 704:

	1
3		0

그림문자(GHS)

1,2,3,4-Tetrahydroquinoline MSDS

1,2,3,4-Tetrahydroquinoline 화학적 특성, 용도, 생산

화학적 성질
Clear pale yellow to yellow liquid. It is easily oxidized in air and may acquire a pale amber colour if exposed to air and daylight. Solidifies in the cold.
용도
1,2,3,4-Tetrahydroquinoline is a reagent used in the synthesis of N-substituted benzoyl-1,2,3,4-tetrahydroquinolyl-1-carboxamides displaying fungicidal activity.
정의
ChEBI: A member of the class of quinolines that is the 1,2,3,4-tetrahydro derivative of quinoline.
Synthesis
1,2,3,4-Tetrahydroquinoline is synthesised using quinoline N-oxide as a raw material by chemical reaction. The specific synthesis steps are as follows:
General procedure: In a 1.5 mL reaction vial, B(C6F5)3 (0.025 mmol, 5.0 mol %) was dissolved in chloroform (0.60 mL), towhich diethylsilane (1.75 mmol, 3.5 equiv) was added. After shaking briefly, quinolines (1a-p, 0.50 mmol, 1.0equiv) was subsequently added to the above catalyst solution under argon atmosphere. The reaction mixturewas stirred at 25-65 oC for 6-24 h for the reaction of 1a-h, and at 25-100 oC for 2-24 h for the reaction of 1i-p,then allowed to cool down to room temperature and concentrated under reduced pressure to give the crudeproduct. This reaction mixture was then treated with 0.25 N HCl ethereal solution (7 mL) and stirred at roomtemperature for 1 h to give the solid residue, which was subsequently washed with ether. The solid residue wasthen dissolved or suspended in MeOH (1.0 mL) and neutralized with Na₂CO₃·H₂O (0.5 g) at 0 oC. After stirringfor 2 h, MeOH was removed under reduced pressure, and the neutralized reaction residue was dissolved inCH₂Cl₂ and washed with brine (5 mL) and water (5 mL). The crude product was then obtained from the organicphase of CH₂Cl₂ solution and finally purified by column chromatography on silica gel to give 2a-h(EtOAc/Hexane = 1/9) and 2i-p (EtOAc/Hexane = 3/7).

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