HMGB1 Monoclonal Antibody (Clone IMG19N10B7)

HMGB1 Monoclonal Antibody (Clone IMG19N10B7) 화학적 특성, 용도, 생산

• 개요

  High Mobility Group Protein B₁ (HMGB1) belongs to the HMGB family and contains two HMG box DNA-binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE). It is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury.

HMGB1 Monoclonal Antibody (Clone IMG19N10B7) 공급 업체

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