알다1

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

• 유해·위험 문구

  H301：삼키면 유독함

  H400：수생생물에 매우 유독함

• 예방조치문구

  P273：환경으로 배출하지 마시오.

  P301+P310：삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.

알다1 화학적 특성, 용도, 생산

• 용도

  Alda-1 has been used as an aldehyde dehydrogenase 2 (ALDH2) agonist:
  
  • to study its cryoprotective effects on H₂O₂-induced Achilles tendinopathy in mice Achilles tenocytes
  • to study its protective effects against alcohol-derived DNA damage in ALDH2 knock out mice
  • to study its effects on cutaneous wound healing in mice
  
  

• Biochem/physiol Actions

  Alda-1 is an ALDH2 agonist; cell-permeable activator of both the wild-type ALDH2*1 and the asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2. ALDH2 is the oxidative enzyme, which removes the ethanol metabolite acetaldehyde and other aliphatic aldehydes. Also. ALDH2 is involved in bioconversion of vasodilator nitroglycerin to nitric oxide. Alda-1 increases acetaldehyde oxidation by ALDH2*1 (wild type) and ALDH2*2 9 Asian variant) approximately 1.5- and 6-fold, respectively. It appears that Alda-1 stimulates acetaldehyde oxidation by ALDH2 by improving NAD binding, but does not improve the nitroglycerin binding affinity of the Asian variant.

알다1 공급 업체

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