REMODULIN

한글명:REMODULIN

카스 번호81846-19-7

상품명:REMODULIN

CBNumberCB7231250

분자식C23H34O5

포뮬러 무게390.51

MOL 파일81846-19-7.mol

화학적 성질

녹는점	121-123°
끓는 점	587.1±50.0 °C(Predicted)
밀도	1.158±0.06 g/cm3(Predicted)
저장 조건	Sealed in dry,Store in freezer, under -20°C
용해도	클로로포름(약간 용해됨, 가열), 메탄올(약간 용해됨, 가열)
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	3.19±0.10(Predicted)
색상	미색부터 베이지까지

그림문자(GHS)

REMODULIN 화학적 특성, 용도, 생산

용도
Synthetic analog of Prostacyclin (P839060). Antihypertensive. Treprostinil, marketed under the trade name Remodulin is a medication used to treat pulmonary arterial hypertension (PAH).
Pharmacokinetics
Treprostinil is rapidly absorbed from the subcutaneous site of infusion, with an almost 100% bioavailability and a mean half-life of 85 minutes (34 minutes for the IV infusion). The IV solution must be diluted with normal saline or sterile water before starting the infusion. Unlike epoprostenol, treprostinil is stable at room temperature for up to 5 years, with vasodilation action lasting from 4 to 6 hours, compared with the short, 2- to 3-minute action for epoprostenol. Because of its long life in the body, it can be administered under the skin with a microinfusion subcutaneous infusion pump rather than into the bloodstream and, thus, without hospitalization, as contrasted with the central IV infusion of epoprostenol.
Clinical Use
Treprostinil is a synthetic, stable form of prostacyclin for the treatment for advanced pulmonary hypertension with NYHA class III or IV symptoms as well as for late-stage peripheral vascular disease (PVD). Its sodium salt injectable form is administered either as a continuous subcutaneous infusion directly into the skin or, if the subcutaneous infusion is not tolerated, as a continuous IV infusion without an implanted catheter.
부작용
Side effects include jaw pain, headaches, nausea, diarrhea, flushing, and localized pain at the delivery site under the skin. This pain has been reported as slight to severe irritation. Patients using the drug seem to ex-perience improvement in their condition, including decreased fatigue, decreased shortness of breath, and decreased pulmonary artery pressures, as well as overall improvement in quality of life.

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