Leuprorelin acetate

한글명:Leuprorelin acetate

카스 번호74381-53-6

상품명:Leuprorelin acetate

CBNumberCB7174300

분자식C61H88N16O14

포뮬러 무게1269.47

MOL 파일74381-53-6.mol

화학적 성질

녹는점	150-155°C
저장 조건	-20°C
용해도	DMSO(약간 용해됨), 메탄올(약간 용해됨)
물리적 상태	고체
물리적 상태	단단한 모양
색상	흰색에서 황백색까지
Merck	14,5457
InChIKey	RGLRXNKKBLIBQS-XNHQSDQCSA-N

위험 및 안전 성명

안전지침서

22-24/25

WGK 독일

RTECS 번호

OH6390000

HS 번호

29371900

NFPA 704:

	0
3		0

그림문자(GHS)

Leuprorelin acetate 화학적 특성, 용도, 생산

개요
Leuprolide acetate is a potent analog of LH-RH useful in achieving a medical castration in the treatment of advanced prostate cancer. It has also been investigated for the treatment of advanced breast cancer.
화학적 성질
Fluffy Solid
용도
Synthetic nonapeptide agonist analog of LH-RH. Antineoplastic (hormonal).
정의
ChEBI: An acetate salt obtained by combining the nonapeptide leuprolide with acetic acid. A long lasting GnRH analog, LH-Rh agonist. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant for the t eatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.
Pharmacology
Leuprolide, 5-oxo-L-prolyl-L-histadyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucil-L-leucil-L-arginyl-N-ethyl-L-prolinamide (30.5.9), is made synthetically.
pyroGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt
The nonapeptide leuprolide is a synthetic analog of the decapeptide, gonadotropin releasing hormone, and it exceeds the activity of the natural hormone and significantly elevates the level of testosterone and dihydrotestosterone in men, and estrogen in women. It also inhibits follicle-stimulating hormone and leutenizing hormone.
Leuprolide is used for prostate cancer, when orchiectomy or estrogen therapy is counterproductive to the patient. A synonym of this drug is lupron.
Drug interactions
Leuprorelin acetate can not take with mang drugs, such as chasteberry, cisapride, dronedarone, pimozide, or thioridazine. This medicine may also interact with the following medications: herbal or dietary supplements, like black cohosh or DHEA; female hormones, like estrogens or progestins and birth control pills, patches, rings, or injections; male hormones, like testosterone; other medicines that prolong the QT interval (abnormal heart rhythm).

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