아난다미드

한글명:아난다미드

카스 번호94421-68-8

상품명:ANANDAMIDE

CBNumberCB7168648

분자식C22H37NO2

포뮬러 무게347.53

MOL 파일94421-68-8.mol

동의어(한글)

아난다미드

화학적 성질

끓는 점	522.3±50.0 °C(Predicted)
밀도	0.92 g/mL at 25 °C (lit.)
인화점	14 °C
저장 조건	-20°C
용해도	에탄올: 가용성
물리적 상태	기름
산도 계수 (pKa)	14.48±0.10(Predicted)
색상	연노랑
수용성	413ug/L(25ºC)
안정성	제공된 대로 구매일로부터 1년 동안 안정적입니다. 산화될 수 있음 – 공기로부터 보호하십시오. 탈기된 DMSO 또는 에탄올 용액은 질소 또는 아르곤 하에서 -80°C에서 최대 1개월 동안 보관할 수 있습니다.

위험 및 안전 성명

위험품 표기	F
위험 카페고리 넘버	11
안전지침서	24/25-16-7
유엔번호(UN No.)	UN 1170 3/PG 2
WGK 독일	3
RTECS 번호	JX3842500

그림문자(GHS)

아난다미드 화학적 특성, 용도, 생산

정의
ChEBI: An N-(polyunsaturated fatty acyl)ethanolamine resulting from the formal condensation of carboxy group of arachidonic acid with amino group of ethanolamine.
위험도
A reproductive hazard.
생물학적 활성
Endogenous cannabinoid and vanilloid receptor agonist, in water-soluble emulsion (for details see TocrisolveTM 100). K i values are 89 and 371 nM for CB 1 and CB 2 receptors respectively; EC 50 values are 18, 31 and 27 nM at GPR55, CB 1 and CB 2 respectively; pK i = 5.68 for rVR1. Also blocks TNF- α -induced NF-kB activation via direct inhibition of IKK. Also available as the pure oil dissolved in ethanol (N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide ).
효소 저해제
This lipid neurotransmitter and endocannabinoid receptor ligand (FW = 347.54 g/mol; CAS 94421-68-8), also known as arachidonylethanolamide, inhibits calcium ion currents and activates the MAP kinase signaling pathway. Anandamide is a naturally occurring effector of central and peripheral nervous systems, as mediated by CB1 and CB2 cannabinoid receptors, respectively. (These receptors were originally characterized as binding Δ9 -tetrahydrocannabinol, or THC, marijuana’s major psychoactive ingredient.) Anandamide, 2-arachidonoylglycerol, and congeners (N- oleoylethanolamide and N-palmitoylethanolamide) are lipophilic signalling molecules with multiple physiological roles in learning and memory, neuroinflammation, oxidative stress, neuroprotection and neurogenesis. Anandamide likewise plays a role in regulating uterine implantation of the early-stage embryo (blastocyst). Anandamide synthesis occurs from N- acetylphosphatidylethanolamine by multiple pathways that include phospholipase A2, phospholipase C, and NAPE-hydrolyzing phospholipase D (or NAPE-PLD). Target(s): adenylate cyclase; Na + channels; a7-nicotinic acetylcholine receptor; 5 HT3 receptors; Ca 2+ channels; K+ channels, voltage-gated; acylglycerol lipase, or monoacylglycerol lipase.

아난다미드 준비 용품 및 원자재

아난다미드 공급 업체

아난다미드 관련 검색

Send Inquriy