P304+P341：들이마신 경우,호흡이 어려운 경우 환자를 신선한 공기가 있는 곳으로 옮기고 호흡하기 편한 자세로 안정을 취하게 함
P342+P311：호흡기 증상이 나타나면 의료기관(의사)의 진찰을 받으시오.
P501：...에 내용물 / 용기를 폐기 하시오.
아실-코엔자임합성효소 화학적 특성, 용도, 생산
화학적 성질
White powder
용도
Acyl-coenzyme A (coA) synthetase from Pseudomonas sp. has been used:
as ligase in the synthesis of mevalonate derivatives of adenosine triphosphate (ATP)
in in vitro fatty acylation assays
in the synthesis of (14C)Vernoloyl-CoA (Va-CoA),(3) bisphosphonates derivatives of ATP(4) and (3H)Palmitate-CoA
일반 설명
Acyl-coenzyme A synthetase belongs to adenylate-forming enzymes superfamily. It has a conserved adenosine triphosphate/adenosine monophosphate (ATP/AMP) binding motif.
Purification Methods
Purify the synthase by extraction with sucrose/HCO3 buffer, protamine sulfate precipitation, (NH4)2SO4 (66-65%) fractination (pH 4.35) and a second (NH4)2SO4 (35-60%) fractionation (pH 4.35). It has Km 0.15mM (Vrel 1.0) for octanoate and 0.41mM (Vrel 2.37) for heptanoate. The Km for ATP is 0.5mM, all at pH 9.0 in ethylene glycol buffer at 38o. [Jencks et al. J Biol Chem 204 453 1953, Methods Enzymol 5 467 1962.]
