SB 223412

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

• 유해·위험 문구

  H301：삼키면 유독함

• 예방조치문구

  P301+P310：삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.

SB 223412 화학적 특성, 용도, 생산

• 개요

  Talnetant is an antagonist of the neurokinin-3 (NK₃) receptor (K_i = 1 nM). It is selective for NK₃ over NK₁ and NK₂ receptors (K_is = 144 and >100,000 nM, respectively, in CHO cells expressing recombinant human receptors). Talnetant inhibits calcium mobilization induced by neurokinin B in HEK293 cells expressing human NK₃ receptors (IC₅₀ = 16.6 nM). It inhibits contractions induced by the NK₃ receptor agonist senktide in isolated rabbit iris sphincter muscle (pD₂ = 9.1). Talnetant (5-20 mg/kg) reduces senktide-induced head shakes and tail whips in mice. It also inhibits senktide-induced wet-dog shakes, increases extracellular dopamine and norepinephrine in the medial prefrontal cortex, and attenuates haloperidol-induced increases in nucleus accumbens dopamine levels in guinea pigs.

SB 223412 준비 용품 및 원자재

SB 223412 공급 업체

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