남성935

남성935 화학적 특성, 용도, 생산

• Originator

  Adimolol hydrochloride ,ZYF Pharm Chemical

• Manufacturing Process

  A mixture consisting of 3 g of 1-(3-amino-3,3-dimethyl-n-propyl) benzimidazolidinone-2, 3.3 g of 1-[naphthyl-(1)-oxyl]propylene-(2,3)-epoxide and 12 ml of 98% ethanol were refluxed for three hours. Thereafter, the ethanol was distilled off, the residue was taken up in some methanol, and the solution was acidified with 1 N hydrochloric acid and then extracted with ethyl acetate. The ethyl acetate was distilled out of the extract solution, and ether and some water were added to the residue, whereupon a crystalline substance separated out. The product was recrystallized from ethanol, yielding 60% of theory of ()-1-(3-((2-hydroxy-3-(1-naphthyloxy)propyl)amino)-3- methylbutyl)-2-benzimidazolinone, which had a melting point of 161°C.
  In practice it is usually used as hydrochloride.

• Therapeutic Function

  Alpa- and Beta-adrenergic blocker

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