졸로페론

졸로페론 화학적 특성, 용도, 생산

• Originator

  Zoloperone,ZYF Pharm Chemical

• Manufacturing Process

  To 20% solution of phosgene in toluene, agitated and cooled to 0°C, are added over 30 min a solution of 1-p-fluoro-benzoyl-1-hydroxy-3-N-[N'-(2- methoxyphenyl)]piperazinopropane and triethylamine in anhydrous chloroform. It is agitated at ambient temperature for 5 h, cooled to 0°C and the solution saturated with gaseous ammonia. The solution is agitated at ambient temperature for 3 h, filtered and the filtrate dried under reduced pressure, 4-ρ-fluorophenyl-5-β-(4-o-methoxyphenylpiperazino)ethyl-4- oxazolin-2-one, melting point 154°C (by alcohol) was obtained.

• Therapeutic Function

  Neuroleptic

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