G-STROPHANTHIN

한글명:G-STROPHANTHIN

카스 번호630-60-4

상품명:G-STROPHANTHIN

CBNumberCB6753829

분자식C29H44O12

포뮬러 무게584.66

MOL 파일630-60-4.mol

화학적 성질

녹는점	200°C
끓는 점	561.69°C (rough estimate)
밀도	1.1941 (rough estimate)
굴절률	-32 ° (C=1, H2O)
저장 조건	Desiccate at -20°C
용해도	H₂O: 차가운 10 mg/mL
산도 계수 (pKa)	13.04±0.70(Predicted)
물리적 상태	가루
색상	하얀색
수용성	13g/L(25℃)
Merck	6901
안정성	흡습성
EPA	Ouabain (630-60-4)

위험 및 안전 성명

위험품 표기	T
위험 카페고리 넘버	23/25-33
안전지침서	45
유엔번호(UN No.)	UN 1544 6.1/PG 1
WGK 독일	3
RTECS 번호	RN3850000
F 고인화성물질	8
유해 물질 데이터	630-60-4(Hazardous Substances Data)
독성	LD50 oral in guinea pig: 8280ug/kg

그림문자(GHS)

그림문자(GHS)
신호 어

Danger
유해·위험 문구

H301：삼키면 유독함

H331：흡입하면 유독함

H373：장기간 또는 반복 노출되면 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킬 수 있음
예방조치문구

P260：분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.

P261：분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.

P264：취급 후에는 손을 철저히 씻으시오.

P264：취급 후에는 손을 철저히 씻으시오.

P270：이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.

P271：옥외 또는 환기가 잘 되는 곳에서만 취급하시오.

P301+P310：삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.

P304+P340：흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.

P311：의료기관(의사)의 진찰을 받으시오.

P314：불편함을 느끼면 의학적인 조치·조언을 구하시오.

P321：(…) 처치를 하시오.

P330：입을 씻어내시오.

P403+P233：용기는 환기가 잘 되는 곳에 단단히 밀폐하여 저장하시오.

P405：밀봉하여 저장하시오.

P501：...에 내용물 / 용기를 폐기 하시오.

G-STROPHANTHIN 화학적 특성, 용도, 생산

개요
One of several cardiac glycosides that have been used clinically as cardiotonic agents and diuretics. Ouabain is obtained from the seeds of Strophanthus gratus, Acokanthera ouabaio, and related species. It was formerly prescribed under the name strophanthuis as the purified seed extract.
화학적 성질
Ouabain is a white crystalline solid.
일반 설명
Odorless, white crystals or crystalline powder as an octahydrate. Used to produce rapid digitalization in acute congestive heart failure. Also recommended in treatment of atrial or nodal paroxysmal tachycardia and atrial flutter.
반응 프로필
When heated to decomposition, G-STROPHANTHIN emits acrid smoke and fumes. Hydrolysis yields one mole ouabagenin and one mole rhamnose. Stable in air, but affected by light (G-STROPHANTHIN octahydrate) [EPA, 1998].
건강위험
G-STROPHANTHIN is classified as extremely toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for 70 kg (150-lb.) person. Exposure may result in respiratory and cardiac failure, and/or hyperalkemia. Patients with frequent premature ventricular heart beats or who have received any preparation of digitalis during preceding three weeks are prone to toxicity.
화재위험
When heated to decomposition, G-STROPHANTHIN emits acrid smoke and fumes. Hydrolysis yields one mole ouabagenin and one mole rhamnose. Stable in air, but affected by light (G-STROPHANTHIN octahydrate)
생물학적 활성
Selective Na + , K + -ATPase inhibitor.
Safety Profile
Poison by ingestion, intramuscular, intraperitoneal, intravenous, subcutaneous, and parented routes. Moderately toxic by intraduodenal route. A cardac stimulant. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes
잠재적 노출
Ouabain, similar to digitoxin, is used to produce rapid digitalization in acute congestive heart failure. Also recommended in treatment of atrial or nodal paroxysmal tachycardia and atrial flutter; enzyme inhibitor.
운송 방법
UN1544 Alkaloids, solid, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Purification Methods
It crystallises from water as the octahydrate. Dry it at 130o. It decomposes at 190o when dry. Store it in the dark as it is light sensitive, but it is stable in air. Its solubility (g/100mL) in H2O is 1.3 (~25o), 20 (~100o), and in EtOH it is 1.0 (~25o) and 12.5 (~78o). It is highly TOXIC as it is an inhibitor of cation transport and of Na+ and K+ ATPase. [Beilstein 18/5 V 625.]
비 호환성
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.).

G-STROPHANTHIN 준비 용품 및 원자재

G-STROPHANTHIN 공급 업체

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