Bosentan hydrate

그림문자(GHS)

Bosentan hydrate 화학적 특성, 용도, 생산

• 용도

  Bosentan hydrate has been used in cell viability assay. It has also been used as a positive control for calcium transient analysis.

• 상표명

  Tracleer (Actelion).

• Biochem/physiol Actions

  Bosentan is an endothelin receptor antagonist. Endothelin is a potent vasoconstrictor, making antagonists of clinical interest for the treatment of conditions associated with vasospasm, such as subarachnoid hemorrhage (SAH) and hypertension. Bosentan is a dual endothelin receptor antagonist effective in the treatment of pulmonary arterial hypertension (PAH), the first of the class to make it to market. Bosentan is an orally available, competitive antagonist of both the ETA and ETB receptor subtypes with a Ki of 4.7 nM for ETA and a Ki of 95 nM for ETB.

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