(S,R,S)-AHPC-PEG6-butyl amine hydrochloride

(S,R,S)-AHPC-PEG6-butyl amine hydrochloride 화학적 특성, 용도, 생산

• 용도

  Protein degrader builiding block (S,R,S)-AHPC-PEG₆-butyl amine (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

(S,R,S)-AHPC-PEG6-butyl amine hydrochloride 공급 업체

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