Demecarium bromide

한글명:Demecarium bromide

카스 번호56-94-0

상품명:Demecarium bromide

CBNumberCB6501408

분자식C32H52Br2N4O4

포뮬러 무게716.59

MOL 파일56-94-0.mol

화학적 성질

녹는점	162-167 °C (decomp)
저장 조건	Store at -20°C
용해도	DMSO:160.0(Max Conc. mg/mL);223.28(Max Conc. mM)
물리적 상태	고체
물리적 상태	단단한 모양
색상	하얀색
InChIKey	YHKBUDZECQDYBR-UHFFFAOYSA-L
SMILES	C1(=CC=CC([N+](C)(C)C)=C1)OC(=O)N(C)CCCCCCCCCCN(C)C(=O)OC1=CC=CC([N+](C)(C)C)=C1.[Br-].[Br-]
CAS 데이터베이스	56-94-0(CAS DataBase Reference)

위험 및 안전 성명

HS 번호	2924296000
유해 물질 데이터	56-94-0(Hazardous Substances Data)

그림문자(GHS)

Demecarium bromide MSDS

Demecarium bromide 화학적 특성, 용도, 생산

화학적 성질
White Solid
용도
Demecarium is a disymmetrical compound that contains two ammonium and two carbamate groups. It is a reversible cholinesterase inhibitor that is longer lasting than the others. It is used to constrict pupils, elevate intraocular pressure in treating glaucoma, and also for alleviating atropine mydriasis.
용도
Demecarium Bromide is an acetylcholinesterase inhibitor and veterinary medicine used to treat elevated intraocular pressure associated with primary glaucoma.
정의
ChEBI: The methobromide salt of the N,N'-bis[3-(dimethylamino)phenyl carbamate] derivative of 2,13-diazatetradecane. It is an inhibitor of acetylcholinesterase and pseudocholinesterase, with a long duration of action. It is u ed in the treatment of chronic open-angle glaucoma: in the eye, it causes constriction of the iris sphincter muscle and the ciliary muscle, facilitating the outflow of the aqueous humor and so reducing intraocular pressure.
일반 설명
Demecarium bromide,(m-hydroxyphenyl)trimethylammonium bromide, decamethylenebis[methylcarbamate] (Humorsol), is the diester of(m-hydroxyphenyl)trimethylammonium bromide with decamethylene-bis-(methylcarbamic acid) and thus is comparableto a bis-prostigmine molecule.
It occurs as a slightly hygroscopic powder that is freelysoluble in water or alcohol. Ophthalmic solutions of the drughave a pH of 5 to 7.5. Aqueous solutions are stable and maybe sterilized by heat. Its efficacy and toxicity are comparableto those of other potent anticholinesterase inhibitor drugs. Itis a long-acting miotic used to treat wide-angle glaucomaand accommodative esotropia. Maximal effect occurs hoursafter administration, and the effect may persist for days.
Synthesis
Demecarium, N,N??-decamethylene-bis-[meta-(N-methylcarbamoyloxy)- phenyl-trimethylammonium] hydroxide (13.2.18), is made by reacting two moles of phosgene with 1,10-bis-(methylamino)-decano(N,N??-dimethyldecamethylen-1,10-diamine, giving the bis-carbamoylchloride (13.2.16), which is transformed into bis-carbamoylester (13.2.17) by reaction with two moles of the 3-dimethylaminophenol sodium salt. Reacting this with methylbromide gives demecarium (13.2.18) [49].

Demecarium bromide 준비 용품 및 원자재

Demecarium bromide 공급 업체

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