InSolution PARP Inhibitor VIII, PJ34 - Calbiochem

InSolution PARP Inhibitor VIII, PJ34 - Calbiochem 화학적 특성, 용도, 생산

• 일반 설명

  A water-soluble phenanthridinone derivative that acts as a potent anti-inflammatory agent and a reversible inhibitor of poly(ADP-ribose) polymerase (PARP; EC₅₀ = 20 nM). Shown to be about 10,000-fold more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350) (EC₅₀ = 200 μM). Suppresses neutrophil infiltration and nitric oxide production in peritonitis. Does not act as an antioxidant even at higher concentrations (1 μM to 10 μM). PJ34 inhibits peroxynitrite-induced cell necrosis with an (EC₅₀ = 20 nM). Exhibits neuroprotective effects in in vivo and in vitro models of stroke. The solid form of this compound (Cat. No. 528150) is also available.

• Biochem/physiol Actions

  Cell permeable: yes

InSolution PARP Inhibitor VIII, PJ34 - Calbiochem 공급 업체

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