CFTR Inhibitor III, OXO-172 - Calbiochem

CFTR Inhibitor III, OXO-172 - Calbiochem 화학적 특성, 용도, 생산

• 일반 설명

  A cell-permeable CFTR_inh-172 (Cat. No. 219670) 2-oxo analog that exhibits ~25-fold higher aqueous solubility than the 2-thioxo CFTR_inh-172 (420 μM vs. 17 μM, respectively, in PBS with 2% DMSO at 25 °C) and great potency, albeit slightly weaker than that of CFTR_inh-172, in inhibiting CFTR-mediated apical membrane chloride current upon 20 μM Forskolin (Cat. No. 344270) stimulation in CFTR-expressing FRT cells (IC₅₀ = 1.4 μM vs. 0.38 μM with CFTR_inh-172) with practically no cytotoxicity (91% of no-drug control FRT in viability assay; 48 h at 50 μM).

CFTR Inhibitor III, OXO-172 - Calbiochem 공급 업체

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