Ketorolac

한글명:Ketorolac

카스 번호74103-06-3

상품명:Ketorolac

CBNumberCB6392833

분자식C15H13NO3

포뮬러 무게255.27

MOL 파일74103-06-3.mol

화학적 성질

녹는점	160-161°C
끓는 점	493.2±40.0 °C(Predicted)
밀도	1.33±0.1 g/cm3(Predicted)
저장 조건	2-8°C
용해도	클로로포름(약간 용해됨), 메탄올(약간 용해됨)
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	3.49 ±0.02(at 25℃)
색상	회백색
수용성	183mg/L(32℃)
CAS 데이터베이스	74103-06-3(CAS DataBase Reference)
EPA	1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro- (74103-06-3)

위험 및 안전 성명

유엔번호(UN No.)

3249

위험 등급

6.1(a)

포장분류

HS 번호

2933998090

독성

LD50 orally in mice: ~200 mg/kg (Rooks)

NFPA 704:

	0
2		0

그림문자(GHS)

Ketorolac 화학적 특성, 용도, 생산

화학적 성질
Light yellow solid
용도
antiarrhythmic
Indications
Ketorolac (Toradol), an NSAID chemically related to indomethacin and tolmetin, is mainly used as an analgesic, not for the treatment of inflammatory disease. It is available in oral, parenteral, and topical formulations.
World Health Organization (WHO)
Ketorolac is a nonsteroidal anti-inflammatory agent used in the management of moderate to severe acute post-operative pain. It remains on the market in many countries with restrictions on its use.
Biological Functions
Ketorolac (Toradol) is an NSAID with very mild antiinflammatory and antipyretic activity. It is a potent analgesic for postoperative pain. Its efficacy is equivalent to that of low doses of morphine in the control of pain. For this reason it is often combined with opioids to reduce opioid dose and related side effects while providing adequate pain relief. It is also used to replace the opioids in some patients with opioid sensitivity. The mechanism of action of ketorolac involves the inhibition of COX and decreased formation of prostaglandins. However, some evidence exists that ketorolac may stimulate the release of endogenous opioids as a part of its analgesic activity.
일반 설명
Ketorolac tromethamine (Toradol), marketed as a mixture of(R)- and (S)-ketorolac enantiomers, is a potent NSAID analgesicindicated for the treatment of moderately severe, acutepain. It should be noted that the pharmacokinetic dispositionof ketorolac in humans is subject to marked enantioselectivity.Thus, it is important to monitor the individual blood levelsso an accurate assessment of its therapeutic action can bemade correctly. However, it should be noted that, beingone of the conventional NSAIDs with highest risk of GIcomplications, its administration should not exceed 5 days.

Ketorolac 준비 용품 및 원자재

Ketorolac 공급 업체

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