클로르프로티센

한글명:클로르프로티센

카스 번호113-59-7

상품명:Chlorprothixene

CBNumberCB6361448

분자식C18H18ClNS

포뮬러 무게315.86

MOL 파일113-59-7.mol

동의어(한글)

클로르프로티센

클로르프로틱센

화학적 성질

녹는점	97-98°
끓는 점	160 °C(Press: 0.04 Torr)
밀도	1.1048 (rough estimate)
굴절률	1.6000 (estimate)
저장 조건	Inert atmosphere,2-8°C
용해도	DMSO : 33.33 mg/mL (105.52 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
물리적 상태	powder to crystal
산도 계수 (pKa)	pKa 8.4(H2O) (Uncertain)
색상	White to Orange to Green
수용성	385.8ug/L(22.5ºC)
안정성	흡습성
NIST	Chlorprothixene(113-59-7)

위험 및 안전 성명

HS 번호

2934.99.3000

유해 물질 데이터

113-59-7(Hazardous Substances Data)

독성

LD50 oral in rabbit: 182mg/kg

NFPA 704:

	0
3		0

그림문자(GHS)

클로르프로티센 화학적 특성, 용도, 생산

개요
In 2002, the American Association of Poison Control Centers’ Toxic Exposure Surveillance System reported 5224 human exposures to phenothiazines, thioxanthenes, and other neuroleptic medications; 3691 were in adults and 808 in children. Unintentional and intentional exposures accounted for 43.7 and 47.8%, respectively. There were 417 (8.0%) adverse drug reactions reported. Thioxanthenes are chemical compounds in which the oxygen atom in xanthene is replaced with a sulfur atom. They are also related to phenothiazines. Several derivatives are used as typical antipsychotics in the treatment of schizophrenia and other psychoses. The thioxanthenes, as a class, are closely related chemically to the phenothiazines. The major structural difference is that the nitrogen at position 10 in the phenothiazines is replaced by a carbon atom with a double bond to the side chain, as shown in the chemical structure of flupenthixol, which has a double-bonded carbon in the number 10 position. Clopenthixol is a typical antipsychotic drug of the thioxanthenes class and a racemic mixture of cis and trans isomers. Zuclopenthixol, the pure cis isomer, has been much more widely used. Both drugs are equally effective as antipsychotics and have similar adverse effect profiles, but clopenthixol is half as active on a milligram-to-milligram basis and appears to produce more sedation in comparison.
용도
Chlorprothixene has an antipsychotic and sedative action. It has expressed antiemetic activity. It is used in various psychoses, schizophrenia, reactive and neurotic depression with prevalent anxious symptomatology, and in conditions of excitement associated with fear and stress. It may be used in small doses as a sedative agent in neurosis.
환경귀착
Long-range transport: handling of thioxanthenes should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. In case of handling, avoid inhalation and contact with skin, eyes, and clothing, as these materials may be an irritant. These substances are considered nonhazardous for transport.

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