Raloxifene hydrochloride

한글명:Raloxifene hydrochloride

카스 번호82640-04-8

상품명:Raloxifene hydrochloride

CBNumberCB6302366

분자식C28H28ClNO4S

포뮬러 무게510.04

MOL 파일82640-04-8.mol

화학적 성질

녹는점	250-253°C
저장 조건	2-8°C
용해도	DMSO: 28mg/mL, 용해성
물리적 상태	고체
물리적 상태	단단한 모양
색상	연노랑
최대 파장(λmax)	286nm(lit.)
Merck	14,8098
BCS Class	2
InChIKey	BKXVVCILCIUCLG-UHFFFAOYSA-N
SMILES	C1(C(=O)C2C=CC(OCCN3CCCCC3)=CC=2)C2C=CC(O)=CC=2SC=1C1C=CC(O)=CC=1.Cl
CAS 데이터베이스	82640-04-8(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기	Xi
위험 카페고리 넘버	36/37/38
안전지침서	22-24/25
WGK 독일	3
RTECS 번호	PC4956925
HS 번호	2934990002

그림문자(GHS)

Raloxifene hydrochloride 화학적 특성, 용도, 생산

개요
Raloxifene was launched as Evista in the US for the prevention of postmenopausal osteoporosis. It is noteworthy that this molecule was formerly under development as keoxifene for breast cancer and prostatic hypertrophy. Raloxifene can be prepared by acylation of 6-methoxy-2-(4-methoxyphenyl) benzothiophene followed by simultaneous demethylation of both methoxy groups. Raloxifen is a selective estrogen receptor modulator, exerting antiestrogenic action on certain tissues (breast) and also estrogenic action on bone metabolism or serum lipids. In normal early postmenopausal women, 200 mg daily produced a trend towards suppression of estrogen effects. Raloxifen impeded bone loss in osteoporosis. A two-year study in postmenopausal women with an increased risk for osteoporosis showed that Raloxifen markedly prevented non-traumatic vertebral fractures. Results of several clinical studies demonstrated that Raloxifen appreciably reduced the risk of developing breast cancer. Moreover, it had favourable effect on lipid profiles without having the potential side-effects of estrogen-based therapies. Several extensions for different uses of this molecule are planned, for example growth disorder, obesity, colon tumor and skin atrophy. No serious drug-related events have been reported in the limited number of clinical trials.
화학적 성질
Light-Yellow Solid
용도
Raloxifene hydrochloride can be used as a nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic.
정의
ChEBI: A hydrochloride salt resulting from the reaction of equimolar amounts of raloxifene and hydrogen chloride.
일반 설명
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

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