Pramipexole Impurity 4

한글명:Pramipexole Impurity 4

카스 번호104632-25-9

상품명:Pramipexole Impurity 4

CBNumberCB6291554

분자식C10H19Cl2N3S

포뮬러 무게284.25

MOL 파일104632-25-9.mol

화학적 성질

녹는점	288-290°C
저장 조건	2-8°C
용해도	H2O: >20mg/mL
물리적 상태	가루
색상	흰색에서 황백색까지
InChIKey	QMNWXHSYPXQFSK-KLXURFKVSA-N
CAS 데이터베이스	104632-25-9(CAS DataBase Reference)

위험 및 안전 성명

WGK 독일

NFPA 704:

	0
2		0

그림문자(GHS)

Pramipexole Impurity 4 화학적 특성, 용도, 생산

개요
Mirapex, an non ergot derivative, was launched in the US for treatment of Parkinson's disease. It can be prepared by two related routes, 5 steps and 3 steps, both involving an optical resolution with L-(+)-tartaric acid to afford the (S)-isomer. Mechanistically, it is a presynaptic dopamine D₂ autoreceptor agonist which also activates D₃-receptors. It is well absorbed from the GI and excreted in the urine essentially unchanged with a half-life of 8-12 hr. Mirapex had favorable effects on the symptoms without levodopa for patients with advanced PD and allowed a 27% reduction in use of levodopa in combination therapy. It had an adverse events profile similar to other dopamine agonists and in advanced patients reduced the mean "on-off" hr/day from 6 to 4. It was safe but not efficacious in all patients.
화학적 성질
White Crystalline Powder
정의
ChEBI: A hydrochloride that is the anhydrous dihydrochloride salt of pramipexole.
일반 설명
Pramipexole dihydrochloride,(S)-2-amino-6-propylamino-dihydrochloride(Mirapex), is a white to off-white powder soluble in water,slightly soluble in methanol and ethanol, and practically insolublein dichloromethane. Following oral administration,pramipexole is readily absorbed. Pharmacokinetic propertiesdiffer between men and women, with area under the curve(AUC) for each dose level being 35% to 43% greater inwomen, mainly because of a 24% to 27% lower oral clearance.The drug undergoes minimal hepatic biotransformationand is excreted virtually unchanged in the urine by the renaltubular secretion. Pramipexole interacts with drugs excretedby renal tubular secretion (H2-antagonists, diuretics, verapamil,quinidine, quinine), which leads to a decreased clearanceof pramipexole.44,45 Pramipexole is indicated fortreatment of the signs and symptoms of idiopathic PD, aloneor in combination with levodopa. It is also indicated for symptomatictreatment of moderate to severe idiopathic restlesslegs syndrome (RLS).

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