3-[(3-메톡시벤조일)아미노]-4-(4-메틸-1-피페라지닐)벤조산메틸에스테르

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H410：장기적 영향에 의해 수생생물에 매우 유독함

• 예방조치문구

  P273：환경으로 배출하지 마시오.

  P501：...에 내용물 / 용기를 폐기 하시오.

3-[(3-메톡시벤조일)아미노]-4-(4-메틸-1-피페라지닐)벤조산메틸에스테르 화학적 특성, 용도, 생산

• 개요

  WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones. For example, WDR5 is a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3. WDR5 can also be a component of histone acetyltransferase complexes and can directly bind methylated as well as unmodified histones. WDR5-0103 is a small molecule that binds a peptide-binding pocket on WDR5 (K_d = 450 nM), inhibiting the catalytic activity of the MLL core complex in vitro (IC₅₀ = 39 μM).

• 용도

  3-[(3-Methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)benzoic Acid Methyl Ester is an small molecule inhibitor of WDR5, an essential componet of the human trithorax-like famliy of SET1 methyltransferase complexes that carry out trimethylation of histone 3 Lys4.

3-[(3-메톡시벤조일)아미노]-4-(4-메틸-1-피페라지닐)벤조산메틸에스테르 공급 업체

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