설파미드,N-메틸-N-(1-메틸에틸)-

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

  H335：호흡 자극성을 일으킬 수 있음

• 예방조치문구

  P264：취급 후에는 손을 철저히 씻으시오.

  P264：취급 후에는 손을 철저히 씻으시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P302+P352：피부에 묻으면 다량의 물로 씻으시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

  P321：(…) 처치를 하시오.

  P332+P313：피부 자극이 생기면 의학적인 조치· 조언을 구하시오.

  P362：오염된 의복을 벗고 세척 후에 재사용하기

설파미드,N-메틸-N-(1-메틸에틸)- 화학적 특성, 용도, 생산

• 용도

  N-Isopropyl-N-methylsulfamide is an intermediate in the synthesis of unlabeled Saflufenacil-d7 (S081802). Saflufenacil-d7 is the labeled version of Saflufenacil (S081800), which is a herbicide of the pyrimidinedione chemical class used for the preplant burndown and selective preemergence dicot weed control in different field crops. It was found to inhibit protoporphyrinogen IX oxidase (PPO) enzyme.

• Synthesis

  Add 160g of ethanol to a 500ml four-necked flask, stir and cool to -5℃. Then, pass 18g (1.06mol) of ammonia gas, control the temperature at -5～0℃ and add 40g (0.23mol) of N-methyl-N-isopropylaminosulfonyl chloride at 0℃. After the addition is completed, keep warm for 1 hour, then control the vacuum of the reaction solution to -0.07MPa, the water bath temperature to 40℃, and concentrate under reduced pressure to dry solid. Add the solid to 120g of dichloromethane, stir at room temperature for 30 minutes to dissolve, and filter to obtain the filtrate. The filtrate is concentrated to dryness under reduced pressure at -0.07MPa and water bath temperature at 40℃ to obtain 33.7g of the product N-Methyl-N-isopropylsulfamoyl amide (HPLC purity 98.2%, yield 95%).

설파미드,N-메틸-N-(1-메틸에틸)- 공급 업체

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