N-(1-페닐에틸)-2-(피롤리딘-1-일)퀴나졸린-4-아민

N-(1-페닐에틸)-2-(피롤리딘-1-일)퀴나졸린-4-아민 화학적 특성, 용도, 생산

• 개요

  Importazole is a cell-permeable inhibitor of importin-β, which transports cargo molecules bearing a nuclear localization signal into the nucleus. Importazole prevents nuclear import of GFP-tagged nuclear factor of activated T cells (NFAT-GFP) in HEK293 cells (IC₅₀ = 15 μM), which is reversible upon importazole washout. Importazole does not interfere with transportin-mediated nuclear import or chromosomal maintenance 1 (CRM1)-mediated nuclear export. Importazole inhibits nuclear import of topoisomerase IIβ binding protein 1 (TopBP1) in Xenopus egg extracts and of NF-κB in multiple myeloma cells. It also induces defects in spindle and microtubule formation in vitro.

• 용도

  Importazole is an importin-β inhibitor.

• Biochem/physiol Actions

  Importazole is an inhibitor of importin-β transport receptors. During interphase, the transport receptor importin-β carries cargoes into the nucleus, where RanGTP releases them. Importazole somehow disrupts the importin/RAN interaction. Importazole is selective among other transporters. Compounds are imported into, but not out of, cells.

N-(1-페닐에틸)-2-(피롤리딘-1-일)퀴나졸린-4-아민 공급 업체

Global(72)Suppliers