Tert-Butyl 4-(bromomethyl)phenylcarbamate

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

• 유해·위험 문구

  H314：피부에 심한 화상과 눈에 손상을 일으킴

• 예방조치문구

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P301+P312：삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.

  P302+P352：피부에 묻으면 다량의 물로 씻으시오.

Tert-Butyl 4-(bromomethyl)phenylcarbamate 화학적 특성, 용도, 생산

• Synthesis

  To a 1 L round bottom flask was added (4-hydroxymethyl-phenyl)-carbamic acid tert-butyl ester (22.3 g, 0.10 mol) obtained from Examples 2pp through 2ooo, Step 1, dichloromethane (400 mL) and triphenylphospine (31.5 g, 0.12 mol). Upon cooling to 0 °C, N-bromosuccinimide (19.6 g, 0.11 mmol) was added in small portions, and the reaction was allowed to warm to room temperature and stirred under nitrogen for 1 h. The mixture was transferred into a large flask, and hexanes were added until the solution became turbid. The solution was eluted through a plug of silica (300 g) with 1:9 ethyl acetate: hexanes and concentrated to yield Tert-Butyl 4-(bromomethyl)phenylcarbamate (12.8 g, 0.057 mol, 57 percent) as a white solid.

Tert-Butyl 4-(bromomethyl)phenylcarbamate 공급 업체

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