아시빅신

한글명:아시빅신

카스 번호42228-92-2

상품명:ACIVICIN

CBNumberCB6242253

분자식C5H7ClN2O3

포뮬러 무게178.57

MOL 파일42228-92-2.mol

동의어(한글)

아시빅신

화학적 성질

녹는점	>200°C (dec.)
끓는 점	341.6±48.0 °C(Predicted)
밀도	1.85±0.1 g/cm3(Predicted)
저장 조건	2-8°C
용해도	H2O: 용해성10mg/mL(가온)
산도 계수 (pKa)	2.02±0.10(Predicted)
물리적 상태	백색 고체.
색상	흰색에서 베이지색
수용성	따뜻하게 하면 10mg/ml의 물에 용해됩니다.
안정성	흡습성

위험 및 안전 성명

위험품 표기	Xn
위험 카페고리 넘버	20/21/22
안전지침서	36
유엔번호(UN No.)	3172
WGK 독일	3
RTECS 번호	NY2103000
위험 등급	6.1(b)
포장분류	III

그림문자(GHS)

아시빅신 화학적 특성, 용도, 생산

화학적 성질
Off-White Solid
용도
Azaserine and Acivicin are classical and irreversible inhibitors of γ-Glutamyltranspeptidase
정의
ChEBI: An L-alpha-amino acid that is L-alanine in which the methyl group is replaced by a (5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl group. A glutamine analogue antimetabolite, it interferes with lutamate metabolism and several glutamate-dependent synthetic enzymes. It is obtained as a fermentation product of Streptomyces sviceus bacteria.
효소 저해제
This cytotoxic isoxazole and copper chelator (FW = 178.57 g/mol; CAS 42228-92-2; Source: Streptomyces sviceus), also known as L-(aS,5S)-aamino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, AT-125, and NSC165301, strongly inhibitsγ-glutamyl transpeptidase. Its clinical application in cancer treatment failed as a consequence of unacceptable toxicity, and the cause(s) of the desired and undesired biological effects have never been elucidated and only limited information about acivicin-specific targets is available. Target deconvolution by quantitative mass spectrometry (MS) has now revealed acivicin’s preference for the specific aldehyde dehydrogenase known as ALDH4A1 by binding to the catalytic site. Moreover, siRNA-mediated downregulation of ALDH4A1 results in a severe inhibition of cell growth, a finding that may explain acivicin’s cytotoxicity. Targets: Acivicin is thought to be a glutamine analogue, an assumption that is amply supported by its ability to inhibit the following enzymes that possess essential amidohydrolase activities that generate nascent ammonia: asparagine synthetase; carbamoyl-phosphate synthetase; anthranilate synthase; glutamate synthase; CTP symthetase; amidophospho-ribosyltransferase; glutamin(asparagin)ase, or glutaminase-asparaginase; GMP synthase, glutamine-dependent; phosphoribosyl-formylglycinamidine synthetase (formylglycinamidine ribonucleotide synthetase; thiol oxidase; γ-glutamyl hydrolase; imidazole-glycerol phosphate synthetase.

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