AJMALINE

한글명:AJMALINE

카스 번호4360-12-7

상품명:AJMALINE

CBNumberCB6235145

분자식C20H26N2O2

포뮬러 무게326.44

MOL 파일4360-12-7.mol

화학적 성질

녹는점	189°C
알파	D18 +131° (c = 0.4 in chloroform); D20 +144° (c = 0.8 in chloroform)
끓는 점	464.47°C (rough estimate)
밀도	1.1117 (rough estimate)
굴절률	1.6800 (estimate)
저장 조건	2-8°C
용해도	클로로포름 (약간 용해됨), DMSO (약간 용해됨)
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	pKa 8.2 (Uncertain)
색상	하얀색
optical activity	+14420 (CHCl3)
수용성	489.7mg/L(30℃)
Merck	13,194
LogP	1.810

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

25-20/21/22

안전지침서

13-45-36

유엔번호(UN No.)

1544

RTECS 번호

AX8050000

위험 등급

6.1(b)

포장분류

III

독성

LD50 oral in rat: 360mg/kg

NFPA 704:

	0
3		0

그림문자(GHS)

AJMALINE 화학적 특성, 용도, 생산

개요
Rauwolfia (Luo Fu Mu) is derived from the plants Rauvolfia verticillata (Lour.) Baill. and R. yunnanensis Tsiang, and the root is usually used as its medicinal part. R. verticillata (Lour.) Baill. var. hainanensis Tsiang and R. vomitoria Afzel. ex Spreng have been also used as traditional Chinese herb.
Rauwolfia is one of the important traditional herbs in southern China. Its scope of treatment includes cold, fever, sore throat, headache, and dizziness caused by hypertension, abdominal pain and diarrhea, scabies, and so on. Rauwolfia is also used to treat insomniac dizziness, bruises, sprains, and venomous snake bites in folk.
In the “Flora of China,” 135 species of Rauwolfia were recorded, mostly distributed in the tropics and subtropics, a few in the temperate regions. There are nine species, four varieties, and three cultivated species in China.
화학적 성질
White Solid
물리적 성질
Appearance: white or yellowish crystal powder. Melting point: its anhydride is 205– 207?°C. Optical rotation: +144° (chloroform). Solubility: well soluble in organic solvents, such as methanol, ethanol, etc., and slightly soluble in water. Storage temperature: 2–8?°C.
역사
Since 1930s, abundant studies have been focused on the Rauwolfia plants. So far, a total of 91 alkaloids were separated from Rauwolfia, and the identification of the chemical structures was obtained, including 2 non-indole alkaloids (thebaine and papaverine) and 89 indole alkaloids . In accordance with the basic framework, indole alkaloids can be divided into seven classes, such as the ajmaline class, the
용도
An antiarrhythmic agent isolated from Rauwolfia serpentina.
정의
ChEBI: A monoterpenoid indole alkaloid that consists of ajmalan substituted at positions 17 and 21 by hydroxy groups.
Pharmacology
Anti-arrhythmic R. serpentina (She Geng Mu) is the first anti-arrhythmic herbal medicine in the psychiatry history. Ajmaline has a potent anti-arrhythmic effect for treating atrial and ventricular arrhythmias and also has a good effect on the treatment of Wolff-Parkinson-White syndrome. Ajmaline plays a main role in decreasing the permeability of sodium ion on the myocardial cell membrane by moderately inhibiting the sodium channel. The electrophysiological effect of ajmaline is similar to that of quinidine, but it is stronger than quinidine.
In addition, ajmaline has a mild anti-sympathetic effect. It affects sympathetic nerve endings to release more sodium, dilate the coronary artery, relax vascular smooth muscle, and then decrease blood pressure. Therefore, it is suitable for clinical treatment of atrial and ventricular premature beats, pre-excitation syndrome with supraventricular tachycardia, but not suitable for the treatment of paroxysmal
atrial fibrillation and sinus tachycardia.
Clinical Use
Ajmaline has the anti-arrhythmic effects for the treatment of atrial or ventricular extrasystoles, paroxysmal supraventricular or ventricular tachycardia, and paroxysmal atrial fibrillation. The lethal dose for human ranged from 100 to 500?mg/kg.
Purification Methods
Ajmaline crystallises from MeOH or EtOAc containing a little H2O to give the trihydrate m 158-160o. This loses 1H2O at 110o and all H2O at 150o. [Beilstein 23 III/IV 3212.]
참고 문헌
Le Gall., Ann. ph arm. franc., 18,817 (1960)

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