2-MONOPALMITIN

2-MONOPALMITIN 화학적 특성, 용도, 생산

• 개요

  2-Arachidonoyl glycerol (2-AG; ) is an endogenous agonist of the CB₁ and CB₂ cannabinoid receptors. 2-Palmitoyl glycerol is a fatty acid ester that does not bind directly to cannabinoid receptors, nor inhibit adenylyl cyclase, but rather potentiates the activity of 2-AG (and other endocannabinoids) to bind to CB₁ and CB₂ and inhibit adenylyl cyclase. This “entourage” effect has been attributed to blockade of the breakdown and reuptake pathways that normally function to reduce endocannabinoid levels rapidly upon release. 2-Palmitoyl glycerol and related endogenous fatty acid derivatives have been shown to interact with endocannabinoids in the modulation of pain sensitivity.

• 화학적 성질

  White Solid

• 용도

  A biomarker of metabolic responses to hepatotoxicants and carcinogens.

• 정의

  ChEBI: A 2-monoglyceride where the acyl group is hexadecanoyl (palmitoyl).

• 생물학적 활성

  Endogenous fatty acid glycerol ester that enhances activity of 2-arachidonylglycerol ((5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic acid,2-hydroxy-1-(hydroxymethyl)ethyl ester ). Does not bind to CB 1 or CB 2 cannabinoid receptors, but potentiates the apparent binding of 2-AG and increases its ability to inhibit adenylyl cyclase. Enhances in vivo cannabinoid effects of 2-AG following combined administration with 2-linoleoylglycerol.

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