bermoprofen

bermoprofen 화학적 특성, 용도, 생산

• Originator

  Bermoprofen,ZYF Pharm Chemical

• Manufacturing Process

  A mixture of dl-2-[4-(2'-carboxymethyl-4'-methylphenoxy)phenyl]propionic acid (15.3 g) and polyphosphoric acid (92 g) was heated with stirring at 110- 120°C for 2 hours. To the reaction mixture was added water and the resulting mixture was extracted with chloroform. The organic layer was washed with water, dried over anhydrous sodium sulfate and concentrated. The residue was chromatographed on silica gel (75 g) using chloroform as an eluent to give a crude product, which was recrystallized from toluene to give the dl-2-(8- methyl-10,11-dihydro-11-oxodibenz[b,f]oxepin-2-yl)propionic acid (9.4 g, 65.3%), m.p. 128-129°C.

• Therapeutic Function

  Antiinflammatory, Antipyretic

bermoprofen 준비 용품 및 원자재

bermoprofen 공급 업체

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