4-아미노페놀

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H317：알레르기성 피부 반응을 일으킬 수 있음

  H341：유전적인 결함을 일으킬 것으로 의심됨 (노출되어도 생식세포 유전독성을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재)

  H373：장기간 또는 반복 노출되면 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킬 수 있음

  H410：장기적 영향에 의해 수생생물에 매우 유독함

• 예방조치문구

  P273：환경으로 배출하지 마시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P301+P312：삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.

  P302+P352：피부에 묻으면 다량의 물로 씻으시오.

  P308+P313：노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.

4-아미노페놀 MSDS

• 4-Aminophenol

4-아미노페놀 화학적 특성, 용도, 생산

• 개요

  4-Aminophenol, also known as 4-hydroxyaniline, is an organic building block. Its quantification in water samples upto the detection limit of 8×10-10mol l-1 has been proposed by employing single-wall carbon nanotubes (SWNT)-nafion film coated glassy carbon electrodes. It is present as the main contaminant in pharmaceutical formulations of paracetamol. High-performance liquid chromatographic (HPLC) method with amperometric detection has been reported for its determination in various analgesic formulations. It has been reported to be formed from the reduction of 4-nitrophenol (Nip) under metal-free conditions catalyzed by N-doped graphene (NG).

• 화학적 성질

  o-Aminophenol appears as colorless needles or as white crystalline substance turning tan to brown on exposure to air. slightly soluble in water and ethanol, insoluble in benzene and chloroform, and quickly turns brown when dissolved in lye.

• 용도

  4-Aminophenol is suitable for use in the synthesis of 2,2-bis(4-aminophenoxy) benzonitrile [4-APBN], a monomer required for the preparation of series of polyamides and poly(amide-imide)s. It may be used as derivatization reagent to improve the ionization of aliphatic and aromatic aldehydes by paper spray ionization mass spectrometry.

• 제조 방법

  Conventionally 4-aminophenol was manufactured using iron-acid reduction of p-nitrobenzene. Reduction using iron-acid is a multi-step process. The modern method is the catalytic dehydrogenation of nitrobenzene to 4-aminophenol using a noble metal catalyst in the presence of an acidic medium. This method also produces aniline as a side-product. The advantage of a reduction using a noble metal catalyst is that it involves a single step reaction, an environment friendly and more efficient process, as there is no evolution of an environmentally harmful gas. Moreover, the side-product aniline is also a valuable chemical.
  
  synthesis of 4-aminophenol

• 주요 응용

  The main and the most significant use of 4-Aminophenol is for the manufacturing of Paracetamol, an analgesic and antipyretic drug. In addition to paracetamol, it is a key element in the synthesis of pharmaceutical ingredients and important industrial chemicals like Acebutolol, Ambroxol, Sorafenib and so on.
  4-Aminophenol is used as a dye for textiles, hair, furs and feathers, and is also used as a developing agent in photography for creating black and white images. It acts as a corrosion inhibitor in paints and as anti-corrosive lubricating agent in 2-cycle engines. It is also used as a wood stain, giving rose-like colour to timber. p-Aminophenol is one of key ingredients for synthesis of rubber antioxidants. Moreover, it is often used as a reagent for analysing metals like Copper, Magnesium, Vanadium and Gold, compounds like Nitrites and Cyanates, and antioxidants.

• 정의

  ChEBI: 4-aminophenol is an amino phenol (one of the three possible isomers) which has the single amino substituent located para to the phenolic -OH group. It has a role as a metabolite and an allergen.

• 일반 설명

  P-aminophenol appears as white or reddish-yellow crystals or light brown powder. Turns violet when exposed to light. (NTP, 1992)

• 공기와 물의 반응

  Insoluble in water.

• 반응 프로필

  Heat (decomposition forming HCN, nitrous vapors, CO); water (CO2); reacts violently with acids, bases, alcohols and amines causing fire and explosion hazards [Handling Chemicals Safely 1980 p. 647].

• 건강위험

  p-Aminophenol is of moderately low toxicity but has caused dermal sensitization and kidney injury; the potential for producing methemoglobin is of relatively minor importance.
  The oral LD50 in rats was 671 mg/kg.1 Effects included central nervous system depression. A solution of 2.5% applied to abraded skin of rabbits was a mild irritant.1 p- Aminophenol caused dermal sensitization in guinea pigs, and skin sensitization has been reported in humans.2,3 The dermal LD50 in rabbits was greater than 8 g/kg, which strongly suggests that absorption through the skin is minimal.4 Single nonlethal acute doses in rats produced proximal renal tubular necrosis of the pars recta.

• 화재위험

  Flash point data are not available for 4-Aminophenol. 4-Aminophenol is probably combustible.

• 색상 색인 번호

  This hair dye is frequently implicated in contact dermatitis in hairdressers, customers, or people sensitized to para-phenylenediamine, by the way of “blackhenna” temporary tattoos.

• Safety Profile

  Poison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. An allergen and skin and eye irritant. Mutation data reported. Can cause contact dermatitis, bronchial asthma, and methemoglobinemia with cyanosis. When heated to decomposition it emits toxic fumes of NOx,.

• 잠재적 노출

  Workers may be exposed to oAminophenol during its use as a chemical intermediate; in the manufacture of azo and sulfur dyes; and in the photographic industry. There is potential for consumer exposure to o-Aminophenol because of its use in dyeing hair, fur, and leather. The compound is a constituent of 75 registered cosmetic products suggesting the potential for widespread consumer exposure. p-Aminophenol is used mainly as a dye, dye intermediate and as a photographic developer; and in small quantities in analgesic drug preparation. Consumer exposure to p-aminophenol may occur from use as a hairdye or as a component in cosmetic preparations. m-Aminophenol is used mainly as a dye intermediate.

• Solubility in organics

  Very soluble in dimethylsulfoxide Soluble in acetonitrile, ethyl acetate, and acetone Slightly soluble in toluene, diethyl ether, and ethanol Negligible solubility in benzene and chloroform

• 운송 방법

  UN2512 Aminophenols (o-; m-; p-), Hazard Class: 6.1; Labels: 6.1-Poisonous materials

• Purification Methods

  Crystallise it from EtOH, then water, excluding oxygen. It sublimes at 110o/0.3mm. It has been purified by chromatography on alumina with a 1:4 (v/v) mixture of absolute EtOH/*benzene as eluent. [Beilstein 13 IV 1014.]

• 비 호환성

  These phenol/cresol materials can react with oxidizers; reaction may be violent. Incompatible with strong reducing substances such as alkali metals, hydrides, nitrides, and sulfides. Flammable gas (H2) may be generated, and the heat of the reaction may cause the gas to ignite and explode. Heat may be generated by the acidbase reaction with bases; such heating may initiate polymerization of the organic compound. Reacts with boranes, alkalies, aliphatic amines, amides, nitric acid, sulfuric acid. Phenols are sulfonated very readily (e.g., by concentrated sulfuric acid at room temperature). These reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid and can explode when heated. Many phenols form metal salts that may be detonated by mild shock.

• 폐기물 처리

  Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

4-아미노페놀 준비 용품 및 원자재

4-아미노페놀 공급 업체

Global(713)Suppliers

4-아미노페놀 관련 검색