엑스메스탄

한글명:엑스메스탄

카스 번호107868-30-4

상품명:Exemestane

CBNumberCB5760314

분자식C20H24O2

포뮬러 무게296.4

MOL 파일107868-30-4.mol

동의어(한글)

엑스메스탄

화학적 성질

녹는점	155.13°C
끓는 점	453.7±45.0 °C(Predicted)
밀도	1.13±0.1 g/cm3(Predicted)
저장 조건	2-8°C
용해도	DMSO: ≥20mg/mL
물리적 상태	가루
색상	흰색에서 황백색까지
optical activity	[α]/D +250 to +300°, c = 1 in methanol
InChI	InChI=1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1
InChIKey	BFYIZQONLCFLEV-DAELLWKTSA-N
SMILES	C1(=O)C=C2[C@](C)(C=C1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)C(=O)CC3)CC2=C
CAS 데이터베이스	107868-30-4(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기

T,N

위험 카페고리 넘버

60-61-51

안전지침서

53-22-36/37-57

WGK 독일

HS 번호

29372900

유해 물질 데이터

107868-30-4(Hazardous Substances Data)

NFPA 704:

	0
2		0

그림문자(GHS)

엑스메스탄 MSDS

엑스메스탄 화학적 특성, 용도, 생산

개요
Exemestane was launched in US and other countries for the treatment of estrogendependent tumors and postmenopausal breast cancer. It is a novel steroidal compound structurally related to the natural substrate for the biosynthesis of estrogen, androstanedione, and can be synthesized by methylidenation of androsta-1, 4-dien- 17beta-ol-3-one in 6 position then oxidation of the alcohol function. Exemestane is an irreversible inactivator of the aromatase enzyme system, so inducing in vivo a dose-related sustained suppression of serum estrogen and minimal endocrine activity. It is the first steroidal representative of the third-generation of orally active aromatase inhibitors with a highly potent and selective mechanism of action, displaying good tolerability and safety profile. In rats with DMBA-induced mammary tumors, 10 to 100 mglkg of exemestan administered po twice-daily for 4 weeks resulted in 76 to 88% regression. In women failing anti-estrogen therapy with tamoxifen, this agent has demonstrated high activity in locally advanced or metastatic disease. In addition, it may also have potential for breast cancer prevention.
화학적 성질
white to light yellow crystal powder
용도
Labeled Exemestane, intended for use as an internal standard for the quantification of Exemestane by GC- or LC-mass spectrometry.
정의
ChEBI: A 17-oxo steroid that is androsta-1,4-diene-3,17-dione in which the hydrogens at position 6 are replaced by a double bond to a methylene group. A selective inhibitor of the aromatase (oestrogen synthase) system, it is used in the treatment of advanced brea t cancer.
일반 설명
Exemestane, 6-methylenandrosta-1,4-diene-3,17-dione (Aromasin), is the first steroid-basedaromatase inhibitor approved for the treatment of breastcancer in the United States. It is a mechanism-based inactivatorthat irreversibly inhibits the enzyme. Plasma estrogenlevels are reduced by 85% to 95% within 2 to 3 days, and effectslast 4 to 5 days. Exemestane does not inhibit any of themajor cytochromes P450 and has essentially no interactionwith steroid receptors, with only a very weak affinity for theAR. The 17β-hydroxyexemestane reduction product, however,has much higher affinity for the AR than the parent(still several fold less than DHT, 0.28% for parent vs. 30%for metabolite). The clinical significance of the affinity islikely minimal because of the low levels of the metaboliteproduced.
위험도
A reproductive hazard.

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