Naloxone
한글명:Naloxone
카스 번호465-65-6
상품명:Naloxone
CBNumberCB5728727
분자식C19H21NO4
포뮬러 무게327.37
MOL 파일465-65-6.mol
동의어(한글)
날록손
화학적 성질
녹는점 | 184° (Lewenstein), 177-178° (Sankyo Co.) |
알파 | D20 -194.5° (c = 0.93 in CHCl3) |
끓는 점 | 465.27°C (rough estimate) |
밀도 | 1.2223 (rough estimate) |
굴절률 | 1.5000 (estimate) |
인화점 | 9℃ |
저장 조건 | 2-8°C |
용해도 | 클로로포름(약간 용해됨,가열, 초음파 처리), DMSO (약간 용해됨), 메탄올 (약간 용해됨), |
물리적 상태 | 고체 |
물리적 상태 | 단단한 모양 |
산도 계수 (pKa) | pKa 7.94/7.82(H2O,t =20/37,I<0.01) (Uncertain) |
색상 | 흰색에서 황백색까지 |
InChIKey | UZHSEJADLWPNLE-GRGSLBFTSA-N |
EPA | Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5.alpha.)- (465-65-6) |
위험품 표기 | F,T |
위험 카페고리 넘버 | 11-23/24/25-39/23/24/25 |
안전지침서 | 7-16-36/37-45 |
유엔번호(UN No.) | UN1230 - class 3 - PG 2 - Methanol, solution |
WGK 독일 | 3 |
HS 번호 | 2939190000 |
유해 물질 데이터 | 465-65-6(Hazardous Substances Data) |
독성 | An opiate antagonist devoid of agonist activity except for mild, specific effects at very high doses. Naloxone displays a high affinity for the μ-opioid receptor, a lesser affinity for the kopioid receptor and has some affinity for δ-opioid receptor subtypes. Naloxone produces a rapid and profound reversal of the effects of opioid administration (e.g., 1 mg, i.v., blocks the effects of 25 mg of heroin). Naloxone also antagonizes the analgesia induced by placebo, acupuncture, and stress, and in animals the hypotension due to hypovolemia or spinal cord injury. Naloxone has a short half-life (about 1 h in plasma) and is not administered orally because of rapid, “first-pass” metabolism. |