Chlorpromazine

한글명:Chlorpromazine

카스 번호50-53-3

상품명:Chlorpromazine

CBNumberCB5547531

분자식C17H19ClN2S

포뮬러 무게318.86

MOL 파일50-53-3.mol

동의어(한글)

클로르프로마진

화학적 성질

녹는점	56.5°C
끓는 점	bp0.8 200-205°
밀도	1.1644 (rough estimate)
굴절률	1.6230 (estimate)
용해도	클로로포름(약간 용해됨), 메탄올(약간 용해됨)
산도 계수 (pKa)	pKa 9.3(H2O,t =24±1) (Uncertain)
물리적 상태	고체
물리적 상태	단단한 모양
색상	흰색에서 황백색까지
NIST	Chlorpromazine(50-53-3)
EPA	Chlorpromazine (50-53-3)

위험 및 안전 성명

유해 물질 데이터	50-53-3(Hazardous Substances Data)
독성	LD50 oral in rat: 142mg/kg

그림문자(GHS)

Chlorpromazine 화학적 특성, 용도, 생산

개요
This phenothiazine with sedative properties is used in human medicines and has induced contact dermatitis in nurses or in those working in the pharmaceutical industry. It is also used in veterinary medicine to avoid mortality of pigs during transportation. It is a sensitizer and a photosensitizer.
화학적 성질
Oily liquid; amine odor.
용도
In psychiatric practice, chlorpromazine is used in various conditions of psychomotor excitement in patients with schizophrenia, chronic paranoid and also manic-depressive conditions, neurosis, alcohol psychosis and neurosis accompanied by excitement, fear, stress, and insomnia. In comparison with other neuroleptics, chlorpromazine is unique in that it has an expressed sedative effect. It is sometimes used in anesthesiological practice for potentiating narcosis. It also has moderate anticonvulsant action.
정의
ChEBI: A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
위험도
Toxic by ingestion.
색상 색인 번호
This phenothiazine with sedative properties is used in human medicine and induced contact dermatitis in nurses or those working in the pharmaceutical industry. It is also used in veterinary medicine to avoid mortality of pigs during transportation. It is a sensitizer and a photosensitizer.
환경귀착
Acute and chronic toxicity due to chlorpromazine generally manifests as an extension of normal pharmacological activity. The precise mechanism of action of chlorpromazine, and other phenothiazines, is unknown; however, it is thought to primarily involve antagonism of dopaminergic (D2) neurotransmission at synaptic sites and blockade of postsynaptic dopamine receptor sites at the subcortical levels of the reticular formation, limbic system, and hypothalamus. This activity contributes to chlorpromazine’s extrapyramidal reactions. Chlorpromazine also has strong central and peripheral activity directed against adrenergic receptors and weak activity against serotonergic, histaminic (H1), and muscarinic receptors. Chlorpromazine has slight ganglionic blocking action. Chlorpromazine is known to depress vasomotor reflexes medicated by the hypothalamus and/or brain stem; inhibit release of growth hormone; antagonize secretion of prolactin release-inhibiting hormone; and reduce secretion of corticotropin-regulatory hormone.
Chlorpromazine also has direct effects on cardiac myocytes; it can induce early after-depolarizations, block depolarizing sodium channels, and cause significant prolongation of the QTc interval.
Chlorpromazine may be irritating to eyes, mucous membranes, and skin. Contact and inhalation should be avoided.
신진 대사 경로
The in vivo photodegradation of chlorpromazine in rat skin exposed to UV-A results in the formation of promazine and 2-hydroxypromazine in irradiated rats, but not in the skin of rats kept in the dark. Chlorpromazine sulfoxide is a major metabolite of chlorpromazine, found in smaller quantity in the skin of irradiated rats compared with those kept in the dark. Chlorpromazine sulfoxide is not a photoproduct of chlorpromazine under the experimental conditions.

Chlorpromazine 준비 용품 및 원자재

Chlorpromazine 공급 업체

Chlorpromazine 관련 검색

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