비아2-093

한글명:비아2-093

카스 번호236395-14-5

상품명:BIA 2-093

CBNumberCB5503197

분자식C17H16N2O3

포뮬러 무게296.32

MOL 파일236395-14-5.mol

동의어(한글)

비아2-093

화학적 성질

녹는점	183-185°C
끓는 점	427.4±55.0 °C(Predicted)
밀도	1.32
저장 조건	Sealed in dry,2-8°C
용해도	H₂O: 불용성
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	13.97±0.40(Predicted)
색상	하얀색
InChIKey	QIALRBLEEWJACW-INIZCTEOSA-N

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

36/37/38

안전지침서

26-36

WGK 독일

HS 번호

2934.99.3000

NFPA 704:

	0
2		0

그림문자(GHS)

비아2-093 화학적 특성, 용도, 생산

개요
Although epilepsy is a neurological disorder with varying etiology and severity, the common feature is unprovoked, recurring seizures. Even when traditional AEDs, such as phenobarbital, phenytoin, carbamazepine, and valproate, control seizure activity, their effectiveness is hampered by considerable side effects and the tendency for drug-drug interactions. Designed for improved efficacy and safety, eslicarbazepine acetate is a third-generation AED that has been approved as adjunctive therapy for partial-onset seizures with or without secondary generalization. As a member of the carbamazepine family (first generation), it is the prodrug of eslicarbazepine and the active metabolite of oxcarbazepine (second generation). .
화학적 성질
White to Off-White Solid
정의
ChEBI: The acetate ester, with S configuration, of licarbazepine. An anticonvulsant, it is approved for use in Europe and the United States as an adjunctive therapy for epilepsy.
부작용
The most common adverse events occurring with an incidence of >2% were dizziness, somnolence, nausea, diplopia, headache, vomiting, abnormal coordination, blurred vision, vertigo, and fatigue. While most of these side effects appeared to be mild to moderate, they did display a dose dependency. Although eslicarbazepine acetate is only contraindicated in patients with a known hypersensitivity to the carbamazepine family of AEDs, caution should be exercised in patients with cardiac conduction abnormalities (potential for prolongations in PR intervals), renal impairment, and in patients of Han Chinese and Thai origin since the presence of HLA-B*1502 allele in these individuals has been shown to be strongly associated with the risk of developing Stevens-Johnson syndrome. Regarding drug interactions, eslicarbazepine acetate may decrease the effectiveness of hormonal contraceptives, so alternative or additional methods of contraception should be considered.

비아2-093 공급 업체

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