7,8-Dihydroxyflavone

한글명:7,8-Dihydroxyflavone

카스 번호38183-03-8

상품명:7,8-Dihydroxyflavone

CBNumberCB5478886

분자식C15H10O4

포뮬러 무게254.24

MOL 파일38183-03-8.mol

화학적 성질

녹는점	243-246°C
끓는 점	494.4±45.0 °C(Predicted)
밀도	1.443±0.06 g/cm3(Predicted)
FEMA	4830 \| 7,8-DIHYDROXYFLAVONE
저장 조건	Inert atmosphere,Room Temperature
용해도	DMSO: 가용성24mg/mL
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	6.86±0.40(Predicted)
색상	노란색 또는 황갈색
안정성	제공된 대로 구매일로부터 1년 동안 안정적입니다. 습기로부터 보호하십시오. DMSO 또는 에탄올 용액은 -20°C에서 최대 1주일 동안 보관할 수 있습니다.
InChI	InChI=1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H
InChIKey	COCYGNDCWFKTMF-UHFFFAOYSA-N
SMILES	C1(C2=CC=CC=C2)OC2=C(O)C(O)=CC=C2C(=O)C=1
LogP	2.760 (est)
CAS 데이터베이스	38183-03-8(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

안전지침서

24/25

WGK 독일

RTECS 번호

DJ3004000

HS 번호

2932990090

NFPA 704:

	1
0		0

그림문자(GHS)

7,8-Dihydroxyflavone 화학적 특성, 용도, 생산

개요
7,8-Dihydroxyflavone(7,8-DHF) is a naturally occurring flavone found in the tree Godmania aesculifolia. It is a selective tyrosine kinase receptor B(TrkB) agonist that has neurotrophic effects in various neurological diseases such as stroke and Parkinson's disease. 7,8-Dihydroxyflavone binds to the TrkB receptors in a similar way to BDNF, or brain derived neurotrophic factor. When the TrkB receptor is activated, neuroprotective and neurogenetive effects occur in neurons, which tend to affect the dendrites. Dendrites are what reach out from the neurons into the synapse to participate in signaling with other neurons. 7,8-DHF has been shown to promote the growth of these dendrites, and to help restore communication between neurons in animal models.
화학적 성질
White crystalline powder or Yellow Solid, soluble in methanol, ethanol, DMSO and other organic solvents, from the dried root of Pulsatilla chinensis (Bge.) Regel.
용도
7,8-Dihydroxyflavone is disubstituted flavone that acts as a small-molecule TrkB agonist. 7,8-Dihydroxyflavone has been shown to reverse memory deficits and BACE1 elevation in a mouse model of Alzheimer''s disease. 7,8-Dihydroxyflavone may also provide a therapeutic option in the treatment of other neorological disorders such as Rett syndrome and PTSD. It has recently been shown to counteract the inhibition of NMDA receptor caused by lead poisoning and confer protective effects in live rats.
생물학적 활성
7,8-Dihydroxyflavone (7,8-DHF) is a monophenolic flavone with diverse effects. It acts as an agonist of the neurotrophic tyrosine kinase receptor TrkB (Kd = 320 nM), protecting neurons that express TrkB from apoptosis. 7,8-DHF is neuroprotective in an animal model of Parkinson’s disease. It supports emotional learning in mice and reverses memory deficits in a mouse model of Alzheimer’s disease. It also improves motor function and extends survival in an animal model of Huntington’s disease. 7,8-DHF inhibits the cytochrome P450 aromatase (IC50 = 10 μM) and, in this way, alters estrogen metabolism. It also has antioxidant action that increases intracellular glutathione synthesis and scavenges reactive oxygen species.

7,8-Dihydroxyflavone 준비 용품 및 원자재

7,8-Dihydroxyflavone 공급 업체

7,8-Dihydroxyflavone 관련 검색

Send Inquriy