IGF-1 (insulin-like growth factor I) is a growth hormone that rapidly stimulate the phosphorylation on tyrosine of a 160 kDa cytosolic protein (pp160) in intact 3T3-L1 adipocytes
정의
Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a protein hormone that plays an important role in childhood growth and continues to have anabolic effects in adults. Measuring IGF-1 levels is used to test for growth hormone deficiency and excess in acromegaly and gigantism. This certified Snap-N-Spike solution of the fully-intact IGF-1 protein is suitable for use as starting material for calibrators and controls in IGF-1 LC/MS testing applications.
일반 설명
IGFs (insulin like growth factors) are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-I expression is regulated by growth hormone. IGF-I signal through the tyrosine kinase type I receptor (IGF-IR). Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and three intra-molecular disulfide bonds.
Clinical Use
Protein of rDNA origin that has orphan
drug status and is used in treating major
burns requiring hospitalization.
Human IGF-I 공급 업체
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