글리세로포스포콜린

한글명:글리세로포스포콜린

카스 번호28319-77-9

상품명:sn-Glycero-3-phosphocholine

CBNumberCB5309777

분자식C8H20NO6P

포뮬러 무게257.22

MOL 파일28319-77-9.mol

동의어(한글)

글리세로포스포콜린

화학적 성질

녹는점	142.5-143°
알파	D25 -2.7° (c = 2.7 in water, pH 2.5); D25 -2.8° (c = 2.6 in water, pH 5.8)
끓는 점	480℃[at 101 325 Pa]
증기압	0Pa at 25℃
인화점	11 °C
저장 조건	-20°C
용해도	DMSO(약간 가열, 초음파 처리), 메탄올(약간 용해됨), 물(약간 용해됨)
물리적 상태	고체
물리적 상태	단단한 모양
색상	흰색에서 황백색까지
수용성	1000g/L at 25℃
안정성	흡습성이 매우 높음
InChI	InChI=1/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/t8-/s3
InChIKey	SUHOQUVVVLNYQR-SBYBRXNCNA-N
SMILES	P([O-])(=O)(OCC[N+](C)(C)C)OC[C@H](O)CO \|&1:12,r\|
LogP	-5.15 at 25℃
CAS 데이터베이스	28319-77-9(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기	F,T
위험 카페고리 넘버	11-23/24/25-39/23/24/25
안전지침서	16-36/37-45-24/25
유엔번호(UN No.)	UN 1230 3/PG 2
WGK 독일	2
RTECS 번호	KH2775000
HS 번호	29239000

그림문자(GHS)

글리세로포스포콜린 MSDS

글리세로포스포콜린 화학적 특성, 용도, 생산

개요
Choline alfoscerate is a nootropic reportedly effective in the treatment of age-associated memory impairment. In man, it decreased and prevented scopolamine-induced amnesia. In vitro studies suggest that choline alfoscerate acts indirectly on cholinergic transmission by elevating the synthesis of acetylcholine.
화학적 성질
Choline glycerophosphate (GPC) is a white waxy solid that is miscible with water, soluble in methanol and ethanol, and insoluble in chloroform, ether, oil, etc. It has no characteristic absorption under UV visible light. The methods for determining GPC content include high-performance liquid chromatography (equipped with an evaporative light scattering detector or refractive index differential detector) and the digestion phosphorus determination method.
용도
sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a phospholipid; precursor in choline biosynthesis. sn-Glycero-3-phosphocholine is an intermediate in catabolic pathway of phosphatidylcholine. sn-Glycero-3-phosphocholine is used as an Nootropic.
정의
ChEBI: Choline alfoscerate is a member of the class of phosphocholines that is the choline ester of sn-glycero-3-phosphate. It is one of the major osmolyte in the renal medullary cells. It has a role as a parasympatholytic, a neuroprotective agent, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a member of sn-glycerol 3-phosphates and a member of phosphocholines.
일반 설명
L-α-Glycerophosphorylcholine is a phospholipid, which is a derivative of phosphatidylcholine.
Synthesis
10 g of phosphorylcholine chloride (1 equivalent, 228 mmol) was dissolved in 200 ml of methanol in a 500 ml three-necked round bottom flask equipped with a thermometer, a reflux condenser and a stirrer. Then, 5.1 g of potassium hydroxide (2 equivalents, 455 mmol) Lt; / RTI & gt; stirred for 1 hour. After warming the reaction to 65 ° C, 10 g of (R) -3-chloro-1,2-propanediol (2 eq, 452 mmol) was added slowly and refluxed for 16 hours to carry out the substitution reaction. After completion of the reaction, 10 ml of water was added to the concentrate obtained by concentration under reduced pressure, and the reaction product was diluted with acetone twice. The aqueous layer was concentrated under reduced pressure to obtain 11.60 g of L-α-glycerophosphorylcholine (sn-Glycero-3-phosphocholine; yield: 99%).

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