Nampt-IN-1

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H302：삼키면 유해함

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

  H335：호흡 자극성을 일으킬 수 있음

• 예방조치문구

  P261：분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

Nampt-IN-1 화학적 특성, 용도, 생산

• 개요

  Nampt-IN-1 is a potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt; IC₅₀ = 3.1 nM). It is selective for Nampt over a panel of greater than 100 human kinases at 1 μM. Nampt-IN-1 inhibits NAD⁺ formation in and proliferation of HCT116 cells (IC₅₀s = 1.8 and 8.9 nM, respectively). It inhibits cell growth in a panel of cancer cell lines (IC₅₀s = <0.2-2 μM). Nampt-IN-1 inhibits NAD⁺ formation in an A2780 ovarian carcinoma mouse xenograft model (ED₅₀ = 2 mg/kg).

• 용도

  Nampt-IN-1 functions as a co-drug. Nampt-IN-1 is a potent and selective NAMPT inhibitor.

• Biochem/physiol Actions

  LSN3154567 might be useful in developing a novel cancer therapeutic.

Nampt-IN-1 공급 업체

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