Vasicine

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H302：삼키면 유해함

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

  H335：호흡 자극성을 일으킬 수 있음

• 예방조치문구

  P261：분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

Vasicine 화학적 특성, 용도, 생산

• 개요

  This quinazoline alkaloid was first isolated from the leaves of Adhatoda vasica Nees by Hooper and subsequently discovered in Peganum harmala under the name Peganine. The base is optically inactive although Spath and Kesztler have reported the isolation of the (-)-form from the fresh leaves of A. vasica and Rosenfeld and Kolesnikow have obtained the same form from the flowers and stems of Peganum harmala. The salts are readily obtained crystalline, e.g. the hydrochloride dihydrate, m.p. 208°C (dry); hydriodide dihydrate, m.p. 195°C (dry); picrate, m.p. 199°C (dec.) and the methiodide, m.p. 187°C.
  With AcOH, the alkaloid gives an anomalous acetyl derivative, m.p. 165°C, subsequently shown to be N-acetylpedadiene. Oxidation with KMn04 gives 4-quinazolone and 4-keto-3 :4-dihydroxyquinazolyl-3-acetic acid, the latter characterized as the methyl ester, m.p. 152°C.
  The crude drug from A. vasica is used in India as a remedy for asthma while the pure alkaloid acts as a bronchodilator.

• 화학적 성질

  White needle-like crystals, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from camels.

• 참고 문헌

  Hooper., Pharm. J., 18,841 (1888)
  Sen, Ghose.,J. Ind. Chem. Soc., 1,315 (1924)
  Ghose., ibid, 4, 1 (1927)
  Spath, Nakawitz., Ber., 67,45 (1934)
  Spath, Kuffner., ibid, 67, 1494 (1934)
  Narang, Ray., Chem. & Ind., 53,698 (1934)
  Hanford, Liang, Adams., J. Amer. Chem. Soc., 56, 2780 (1934)
  Ghoseetal., ibid, 57,921,951 (1935)
  Rosenfeld, Kolesnikov., Ber., 69, 2022 (1936)
  Pharmacology: Chopra., Ind. Med. Gaz., 60, 354 (1925)
  Tutaev, Makarova., Trans. Ukraine Inst. Exp. Pharm., 1,32 (1938)

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