N-palMitoyl-1-deoxysphinganine (M18:0/16:0)

N-palMitoyl-1-deoxysphinganine (M18:0/16:0) 화학적 특성, 용도, 생산

• 일반 설명

  N-C16-deoxysphinganine Commonly referred to as 1-deoxydihydroceramide (1-deoxyDHCer), is the N-acylated form of 1-deoxysphinganine, a potent inhibitor of sphingolipid metabolism. The N-acyl group can be 16, 20 and 24 carbon chain. N-acylsphinganines (dihydroceramides) are synthesized by the acylation of sphingoid bases in the presence of ceramide synthases (CerS).

• Biochem/physiol Actions

  N-acylsphinganines (dihydroceramides) levels are lower during ceramide synthase inhibition. They are intermediates of ceramide and dihydrosphingolipids synthesis. Treatment of MCF7 cancer cells with fenretinide alters sphingolipid metabolism.

N-palMitoyl-1-deoxysphinganine (M18:0/16:0) 공급 업체

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