디[3-데옥시-D-만노-옥툴로소닐]-지질A(aMMonuM염)

디[3-데옥시-D-만노-옥툴로소닐]-지질A(aMMonuM염) 화학적 특성, 용도, 생산

• 용도

  Kdo2-Lipid A (KLA) is a nearly homogeneous Re lipopolysaccharide (LPS) substracture with endotoxin activity equal to tha of native LPS. KLA is comparable to LPS and its activity is reduced by >10^3 in cells fro TLR-4 deficient mice.

• 일반 설명

  3-deoxy-D-manno-octulosonic acid (Kdo2-Lipid A) is the essential component of lipopolysaccharide in most Gram-negative bacteria and the minimal structural component to sustain bacterial viability. It serves as the active component of lipopolysaccharide to stimulate potent host immune responses through the complex of Toll-like-receptor 4 (TLR4) and myeloid differentiation protein 2 (MD2). Therefore, Kdo2-lipid A is an important stimulator for studying the mechanism of the innate immune system and for developing bacterial vaccine adjuvants. Kdo2 Lipid A/TLR4 antagonists can also be applied in anti-inflammatory interventions. Kdo2-lipid A, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy. Kdo2-Lipid A has been used in animal atherosclerosis model.

• Biochem/physiol Actions

  Kdo2-Lipid A might be useful to stimulate inflammatory response.

디[3-데옥시-D-만노-옥툴로소닐]-지질A(aMMonuM염) 공급 업체

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