2-(3,5-Dichlorophenyl)-6-benzoxazole carboxylic acid

한글명:2-(3,5-Dichlorophenyl)-6-benzoxazole carboxylic acid

카스 번호594839-88-0

상품명:2-(3,5-Dichlorophenyl)-6-benzoxazole carboxylic acid

CBNumberCB52484674

분자식C14H7Cl2NO3

포뮬러 무게308.12

MOL 파일594839-88-0.mol

화학적 성질

끓는 점	486.7±40.0 °C(Predicted)
밀도	1.530
저장 조건	-20°
용해도	DMSO에 용해됩니다(최대 20mg/ml).
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	3.49±0.30(Predicted)
색상	회백색
안정성	최대 3개월 동안 -20°의 DMSO에 보관

그림문자(GHS)

2-(3,5-Dichlorophenyl)-6-benzoxazole carboxylic acid 화학적 특성, 용도, 생산

개요
Tafamidis is a kinetic stabilizer of transthyretin (TTR) that prevents amyloidogenesis by wild-type and mutant TTRs. It binds to TTR with negative cooperativity (K_d1 = 3 nM; K_d2 = 278 nM) to stabilize the TTR dimer-dimer interface and inhibit tetrameric dissociation. Tafamidis stabilizes wild-type and clinically significant V30M and V122I mutant TTR amyloidogenic homotetramers (EC₅₀s = 2.7-3.2 μM) under fibril-promoting, denaturing, and physiological conditions in vitro. It stabilizes TTR heterotetramers containing wild-type and mutant subunits ex vivo in human plasma derived from patients carrying V30M or V1221 mutations when used at a concentration of 7.2 μM. Formulations containing tafamidis have been used for the treatment of familial amyloid polyneuropathy.
용도
Tafamidis can be used as a benzoxole derivative that is a transthyretin (TTR) amyloid fibril inhibitors. It is a new drug candidate in the treatment of TTR amyloidosis (caused my misfolding of proteins).
정의
ChEBI: A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazole-6-carboxylic acid in which the hydrogen at position 2 is replaced by a 3,5-dichlorophenyl group. Used (as its meglumine salt) for the amelioration of transthyretin-related hereditary amyloid sis.
Synthesis
The synthesis of 2-(3,5-Dichlorophenyl)-6-benzoxazole carboxylic acid is as follows:
methyl 2-(3,5-dichlorophenyl)benzo[d]oxazole-6-carboxylate (17.9 mmol) was dissolved in a mixture of THF:MeOH:H2O (3:1:1, 50 mL) and treated with LiOH (71.6 mmol) at room temperature for 6h. The mixture was acidified to pH 2 with 1 N HCl and extracted with EA. The combined organic layers were dried over MgSO4, filtered and concentrated to give the product as a white solid 5.0 g, yield 91%.

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