SAXITOXIN
한글명:SAXITOXIN
카스 번호35523-89-8
상품명:SAXITOXIN
CBNumberCB5241547
분자식C10H17N7O4
포뮬러 무게299.29
MOL 파일35523-89-8.mol
화학적 성질
| 끓는 점 | 440.62°C (rough estimate) |
| 밀도 | 1.3010 (rough estimate) |
| 굴절률 | 1.6400 (estimate) |
| 저장 조건 | −20°C |
| 산도 계수 (pKa) | 13.32±0.50(Predicted) |
| optical activity | +13320 (H2O) |
| EPA | Saxitoxin (35523-89-8) |
| 위험품 표기 | T+ |
| 위험 카페고리 넘버 | 26/27/28 |
| 안전지침서 | 36/37/39-45 |
| 유엔번호(UN No.) | UN 3462 6.1/PG 1 |
| WGK 독일 | 3 |
| 독성 | During seasons when dinoflagellates “bloom,” filter-feeding shellfish become contaminated with accumulated toxin and are toxic when eaten. STX blocks nerve membrane sodium channels in nanomolar concentrations when applied externally. STX competes with tetrodotoxin (TTX) for binding to sodium channels. The mechanism of action on nerves is the same as that of TTX, although recovery from STX block occurs slightly faster than that after TTX block. The i.p. LD50 in mice is 10 μg/kg. Symptoms in humans within 30 min of ingestion include tingling and burning in face, lips, tongue, and eventually the whole body, parathesia followed by numbness, ataxia, general motor incoordination, confusion, and headache. Death due to respiratory paralysis occurs within 12 h. Treatment is restricted to symptoms. There is no antidote, and emesis is advisable. Artificial respiration is given if neces_x0002_sary. Prostigmine methylsulfate (1 mL of 1:2000 solution, i.v.) is helpful. |
