LOPRAZOLAM

LOPRAZOLAM 화학적 특성, 용도, 생산

• Originator

  Avlane,J.A.S.M.,France,1981

• Manufacturing Process

  1.1 g of methanesulfonic acid were added dropwise to a mixture of 4.6 g of 8- nitro-1,2-dihydro-2-(N-methylpiperazin-1-yl)methylene-6-(o-chlorophenyl)- 1H,4H-imidazo-[1,2-a][1,4]benzodiazepin-1-one in 100 ml of anhydrous methylene chloride and 5 ml of methanol. Dry ether was slowly added until crystals formed on scratching and the solution was allowed to crystallize with further ether being added to complete the crystallization. The pale yellow solid was filtered off, washed with ether and crystallized from methylene chloridemethanol to obtain 5.4 g of 8-nitro-1,2-dihydro-2-(N-methylpiperazin-1- yl)methylene-6-(o-chlorophenyl)-1H,4H-imidazo-[1,2-a][1,4]-benzodiazepin-1- one methanesulfonate melting at 205°C to 210°C.

• Therapeutic Function

  Tranquilizer

LOPRAZOLAM 준비 용품 및 원자재