RU 58841

한글명:RU 58841

카스 번호154992-24-2

상품명:RU 58841

CBNumberCB51396657

분자식C17H18F3N3O3

포뮬러 무게369.34

MOL 파일154992-24-2.mol

화학적 성질

끓는 점	493.6±55.0 °C(Predicted)
밀도	1.39
저장 조건	Sealed in dry,Store in freezer, under -20°C
용해도	DMF: 33 mg/ml; DMSO: 25 mg/ml; Ethanol: 33 mg/ml; Ethanol:PBS(pH 7.2) (1:5): 0.16 mg/ml
물리적 상태	가루
산도 계수 (pKa)	15.09±0.10(Predicted)
색상	White to off-white
InChI	InChI=1S/C17H18F3N3O3/c1-16(2)14(25)23(15(26)22(16)7-3-4-8-24)12-6-5-11(10-21)13(9-12)17(18,19)20/h5-6,9,24H,3-4,7-8H2,1-2H3
InChIKey	ARBYGDBJECGMGA-UHFFFAOYSA-N
SMILES	C(#N)C1=CC=C(N2C(=O)N(CCCCO)C(C)(C)C2=O)C=C1C(F)(F)F

그림문자(GHS)

RU 58841 화학적 특성, 용도, 생산

개요
RU-58841 is a non-steroidal antiandrogen that binds to the androgen receptor (Kd = 1.8, 1.1, 5.6, 1.3, and 1.4 nM for human, rat, mouse, hamster prostate, and hamster flank organ receptors, respectively). In vivo, topical administration of RU-58841 (1-100 μg per animal) reduces size of the flank organ without affecting sex organs in a dose-dependent manner in hamsters. It has no effect on sex organ weight in intact rats when administered percutaneously, subcutaneously, or orally at doses up to 1 mg per animal. RU-58841 (5% v/v) also induces hair regrowth in the bald frontal scalps of postpubertal stumptailed macaques, a model for male pattern baldness.
용도
RU 58841, is a specific androgen receptor antagonist or anti-androgen, that has shown to have effect on hair growth.
제조 방법
RU58841 is active against baldness and is commercially available. The previously reported synthesis uses phosgene, three discrete inert atmosphere steps and three steps that require flash chromatography. Our synthesis uses no phosgene, only one inert atmosphere step and does not require flash chromatography.
Alternative synthesis of the anti-baldness compound RU58841
Synthesis Reference(s)
A bromine–nitro substitution at tertiary carbon and using 2-nitropropane as leaving group enable a short phosgene-free synthesis of RU58841.

pubs.rsc.org
생물학적 활성
Androgens are mainly produced in the adrenal glands and testes. They are male hormones responsible for sex-related development. The well-known androgen is testosterone. Dihydrotestosterone (DHT) is also an androgen, which is a byproduct of testosterone. Although DHT is important for male development and physical health, it can cause hair loss. RU58841 is a topical anti-androgen drug that counteracts the effects of dihydrotestosterone (DHT) by binding to the androgen receptors of the hair follicles, preventing DHT from interacting with the androgen receptors of the hair follicles. Therefore, the hair shrinkage process does not begin, ensuring that the hair undergoes a normal growth cycle.

RU 58841 준비 용품 및 원자재

RU 58841 공급 업체

Send Inquriy