Pegvisomant

Pegvisomant 화학적 특성, 용도, 생산

• 용도

  Treatment of acromegaly (competitive inhibition of peripheral growth hormone receptors to block IFG-I production).

• Biological Functions

  This product contains 191 amino acid residues (of recombinant origin), the same number as in GH, but there are substitutions at residues 18, 21, 120, 167, 168, 171, 172, 174, and 179. This product is then covalently linked to several polyethylene glycol molecules, and this pegylated protein is a GH-receptor antagonist. Thus, pegvisomant binds to the GH receptor and blocks endogenous GH from binding. The result is a blocking of the GH-stimulated overproduction of IGF-I that contributes to the disabling symptoms and long-term health problems associated with acromegaly.

Pegvisomant 공급 업체

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