아부니다졸

아부니다졸 화학적 특성, 용도, 생산

• Originator

  Abunidazole,ZYF Pharm Chemical

• Manufacturing Process

  150.0 g (1 mol) of p-tert-butylphenol are dissolved in 1200 ml of anhydrous ethyl ether and the thus obtained solution is added to a 10% solution of ethylmagnesium bromide in 1000 ml of anhydrous ether, at room temperature, under stirring.
  After having evaporated the ether, 1000 ml of anhydrous benzene are added and the mixture is distilled, at normal pressure, until its volume is about 2/3 of the original volume. After cooling at room temperature, 1 mol of 1-methyl- 5-nitroimidazolyl-2-carboxyaldehyde in 1000 ml of anhydrous benzene is added.
  The whole is boiled for 1 h, is cooled to about 10°C and is added with 8% HCl to adjust the pH to 7. Benzene layer is dried and concentrated up to 2/3 of the volume. The 2-(1-methyl-5-nitro)imidazolyl-1-(2-hydroxy-5-tertbutylphenylcarbinol is allowed to crystallize, melting point 158°-160°C; yield 0-60%.

• Therapeutic Function

  Antiprotozoal

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