헤프로니케이트

헤프로니케이트 화학적 특성, 용도, 생산

• Originator

  Megrin,Yoshitomi,Japan,1972

• Manufacturing Process

  In 50 ml of pyridine were dissolved 50 grams of nicotinic acid and 50 grams of p-toluene-sulfonyl chloride. While stirring, the mixture gradually became hot and colorless, and finally solidified. To the mixture was added dropwise a solution of 19 grams of 2-hexyl-2-(hydroxymethyl)-1,3-propanediol in 400 ml of pyridine at a temperature below 80°C. The mixture was heated at 115° to 125°C on an oil bath for 1 hour. After cooling, the mixture was poured into 300 ml of ice water, and extracted with toluene. The toluene layer was washed in sequence with water, aqueous sodium carbonate and water, dried over potassium carbonate, and then the toluene was distilled off. The oily residue was crystallized from ethanol to give 30 grams of 2-hexyl-2-(hydroxymethyl)- 1,3-propanediol trinicotinate, melting at 94° to 96°C. The yield was 59.5%.

• Therapeutic Function

  Vasodilator

헤프로니케이트 준비 용품 및 원자재

헤프로니케이트 공급 업체

Global(9)Suppliers