glycosphingolipids is said to replenish the lipids lost from the skin and renew the skin’s barrier function and moisture-binding capacity. When incorporated into aftershave preparations, they also seem to help soothe nicks and cuts. Laboratory studies indicate that glycosphingolipids can reduce transepidermal water loss when applied to the skin, even at 5 percent in a typical oilin-water emulsion. glycosphingolipids, a compound of lipids and sugars, are a class of molecules embedded in the membranes of cells throughout the body where they act to regulate the interaction of healthy cells with their environment.